Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Mu, Yulei; Zhang, Zhen; Zhou, Huiqun; Ma, Liang; Wang, Dong-An

doi:10.1039/d4bm00665h

Biomater. Sci.

2024

DOI: 10.1039/d4bm00665h

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Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Yulei Mu,

Zhen Zhang,

Huiqun Zhou

et al.

Abstract: The innovative and efficacious application of nanotechnology for remodeling the glioblastoma (GBM) tumor microenvironment (TME) exhibits promising potential as a therapeutic avenue for GBM treatment.

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Cited by 4 publications

References 181 publications

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Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

Qindeel,

Irfan,

Ullah

et al. 2024

Journal of Drug Delivery Science and Technology

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Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

Qindeel,

Irfan,

Ullah

et al. 2024

Journal of Drug Delivery Science and Technology

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A biomimetic targeted nanosystem delivering synergistic inhibitors for glioblastoma immune microenvironment reprogramming and treatment

Mu,

Zhang,

Zhou

et al. 2024

Materials Today Bio

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Applications of polymeric nanoparticles in drug delivery for glioblastoma

Liu,

Tan,

Wang

et al. 2025

Front. Pharmacol.

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Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, necessitating innovative therapeutic approaches. Polymer-based nanotechnology has emerged as a promising solution, offering precise drug delivery, enhanced blood-brain barrier (BBB) penetration, and adaptability to the tumor microenvironment (TME). This review explores the diverse applications of polymeric nanoparticles (NPs) in GBM treatment, including delivery of chemotherapeutics, targeted therapeutics, immunotherapeutics, and other agents for radiosensitization and photodynamic therapy. Recent advances in targeted delivery and multifunctional polymer highlight their potential to overcome the challenges that GBM brought, such as heterogeneity of the tumor, BBB limitation, immunosuppressive TME, and consideration of biocompatibility and safety. Meanwhile, the future directions to address these challenges are also proposed. By addressing these obstacles, polymer-based nanotechnology represents a transformative strategy for improving GBM treatment outcomes, paving the way for more effective and patient-specific therapies.

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Applications of nanotechnology in remodeling the tumour microenvironment for glioblastoma treatment

Abstract: The innovative and efficacious application of nanotechnology for remodeling the glioblastoma (GBM) tumor microenvironment (TME) exhibits promising potential as a therapeutic avenue for GBM treatment.

Cited by 4 publications

References 181 publications

Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

Nanotechnology in glioblastoma therapy: Advances in drug delivery systems and diagnostic approaches

A biomimetic targeted nanosystem delivering synergistic inhibitors for glioblastoma immune microenvironment reprogramming and treatment

Applications of polymeric nanoparticles in drug delivery for glioblastoma

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