Applications of photobiomodulation in hearing research: from bench to clinic

Lee, Jae‐Hun; Kim, Sehwan; Jung, Jae Yun; Lee, Min Young

doi:10.1007/s13534-019-00114-y

Cited by 10 publications

(11 citation statements)

References 94 publications

(112 reference statements)

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“…Subgroup analyses were conducted to explore the influence of underlying disorders, including sensorineural hearing loss (SNHL) and idiopathic tinnitus, the length of the irradiation session and different wavelength settings, on the pooled effect estimates, as these factors might cause differences in the effects of LLLT [1,15,16]. In the influence analysis of the THI score after intervention, the pooled point estimates after omitting each included study one at a time lay within the 95% CI of the overall pooled results.…”

Section: Discussionmentioning

confidence: 99%

“…When different parts of the tympanic membrane or mastoid area are illuminated, a different light distribution within the cochlea results. Additionally, increasing the distance between the irradiation fiber tip and the irradiation target leads to attenuation of the transmitted irradiance [15,16]. Therefore, when laser irradiation is administered, the unique anatomy of the ear must be considered, as it may affect the penetration of the irradiance.…”

Section: Discussionmentioning

confidence: 99%

“…The differences may result from inconsistencies in several factors. First, as a higher wavelength laser would deliver a large amount of irradiance through greater penetration [15][16][17], different wavelength settings might affect the efficacy of LLLT. Second, LLLT delivered to the cochlea via the transmastoidal route is expected to be greatly absorbed by temporal bone, leading to therapeutically insufficient doses of irradiation.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

2020

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Study Objective: Tinnitus is a common disorder characterized by sound in the ear in the absence of external or internal stimuli. Low-level laser therapy (LLLT) was discovered enhancing tissue repair via increasing the blood microcirculation and cell proliferation in 1960s. In the last two decades, LLLT delivered to the cochlea has frequently been used to reduce the severity of tinnitus. However, whether LLLT effectively attenuates the severity of tinnitus remains controversial. We aimed to evaluate the efficacy of low-level laser therapy on adult patients with complaints of tinnitus. Design: Systematic review and meta-analysis with trial sequential analysis. Interventions: Low-level laser therapy (LLLT). Measurements: Tinnitus Handicap Inventory (THI) score; improvement rates of the visual analog scale (VAS), verbal rating scale (VRS) and numeric rating scale (NRS) scores. Methods: We searched PubMed, Embase, Scopus, Web of Science, and the Cochrane Library from inception through 17 September 2020. Randomized control trials that involved adult patients with complaints of tinnitus, compared LLLT to a placebo and provided sufficient information for meta-analysis were considered eligible. Main Results: Overall, 11 studies involving 670 patients were included. No significant difference in the overall effect according to the THI score (mean difference (MD), −2.85; 95% CI, −8.99 to 3.28; p = 0.362; I2 = 0%) and the rating scale score improvement rate (risk ratio (RR), 1.35; 95% CI, 0.81 to 2.27; p = 0.250; I2 = 67%) was demonstrated between patients receiving LLLT and those receiving a placebo. None of the subgroup analyses showed significant differences, regardless of underlying sensorineural hearing loss, the number of irradiation sessions or the wavelength used. Conclusions: Our meta-analysis suggests that the value of LLLT in controlling the severity of tinnitus remains unclear, in part due to the relatively small number of patients and underlying heterogeneity. More large-scale investigations of LLLT for tinnitus related to inner ear disease are required to further elucidate the therapeutic effects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy of Low-Level Laser Therapy for Tinnitus: A Systematic Review with Meta-Analysis and Trial Sequential Analysis

2020

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“…The photobiomodulation can benefit various SLH treatments, with satisfactory results especially in oralmotor functions and dysphagia 4,11 . Although most of the research and interventions occur in these fields, the audiology specialists have also been investing in LLL as an intervention resource, as seen in research on the rehabilitation of patients with tinnitus 12,13 .…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation in speech-language-hearing therapy: a profile of professional practice and the level of information of Brazilian speech-language-hearing therapists

et al. 2021

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Purpose: to know the profile of Brazilian speech-language-hearing (SLH) therapists and their level of information on the use of low-level laser photobiomodulation. Methods: an observational, cross-sectional, quantitative study conducted with a self-administered online questionnaire related to the professional education, work, and knowledge of SLH therapists on low-level laser photobiomodulation. Two hundred sixty-one speech-language-hearing therapists of both sexes participated in the research. The data were analyzed with descriptive and inferential statistics. Results: the speech-language-hearing therapists had graduated predominantly 10 to 20 years before, their highest degree was mainly specialization, and most of them worked in the fields of oral-motor functions, dysphagia, voice, language, and audiology. Most of them knew photobiomodulation and its use in SLH therapists; also, they agreed on using a low-level laser as a therapeutic resource. Even so, most did not use it in clinical practice, although those who did, reported greater patient adherence. Statistical significance was verified for the association between laser use and access to resolution number 541 of the Federal Speech-Language-Hearing Council, time in the profession, main specialization, and required qualification. Conclusion: the participating speech-language-hearing therapists showed knowledge on low-level laser photobiomodulation and its applicability. However, most of these professionals did not use the resource yet.

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“…The final two articles of this Special Issue are phototherapeutic in nature, covering a growing interest in the field of photo-bio-modulation (PBM), an emerging therapeutic/treatment augmentation modality in clinical scenarios where current (e.g., pharmacological) treatments are of limited efficacy or yield debilitating side effects. Lee et al describe the spectrum of PBM from the preclinical to the clinical applications in hearing research [8]. The efforts to use PBM to non-invasively improve hearing (including tinnitus) are reviewed, driven by the absence of currently accepted therapeutic modality for properly managing sensorineural hearing loss.…”

mentioning

confidence: 99%