The resin infiltration technology concept is one of the most widely used minimally invasive restorative techniques in restorative dentistry with the most outstanding therapeutic effect, and it is also one of the key research directions in restorative dentistry. "Infiltration resin" is the specialty restorative material for the technology, which is the key factor to success. The specialized restorative material is commonly known as "infiltrant/infiltration resins" "resins infiltrant" "infiltrant" or "resins," which will be consistently referred to as "infiltration resins" throughout the article.‐The paper aims to provide a comprehensive overview of infiltration resins by introducing the development of their therapeutic mechanisms, basic components, current challenges, and future trends, Based on existing literature, we analyze and compare how changes in the base monomer's structure and ratio affect the effectiveness of infiltration resins, from the material's structure‐effective relationship. After compiling the information, the existing solution strategies have been listed to offer substantial support and guidance for future research endeavors.