Applications of planar microfluidic devices and gas chromatography for complex problem solving

Abstract

The application of planar microfluidic devices in GC for the separation of components of interest otherwise difficult to separate in a single analysis is presented. A variety of configurations were used for parallel chromatography, column effluent splitting, back flushing, selectivity tuning, valve less switching and column isolation, heart cutting, and comprehensive multidimensional chromatography. The synergies of recently commercialized planar microfluidic devices combined with the resolving power of fused-silica capillary columns are demonstrated. Difficult separations were accomplished in one single analysis, such as light hydrocarbons in air with high-moisture content, fixed gases in hydrocarbons, trace sulfur containing compounds in natural gas, and oxygenated compounds in hydrocarbons, among others.

Multidimensional GC using planar microfluidic devices for the characterization of phenolic antioxidants in fuels

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Current developments in high‐throughput analysis for microalgae cellular contents

“…The coupling of microfluidic LC and mass spectrometry (LC‐MS) has aided the exploration of human proteomics and biomarkers since 2001 [85]. Several microfluidic techniques are also developed to facilitate the analysis of sample containing complex ingredients in gas chromatography (GC) [86–89]. The microfluidics‐based electrospray ionization developed by Han et al [90] enhanced the separation of lipid classes in samples from mice.…”

A study of the in-column detection performance for chromatography separation

“…Since early of the 90s, LOC has shown advantages that include reduction of reagents consumption, reduced in instrumentation storage space and promised high throughput (Mark et al 2010). To date, LOC has shown great diversity of functions and applications such as micropump (Chee et al 2013), capillary electrophoresis (Huang et al 2008), liquid and gas chromatography (Pruim et al 2012;Zhu et al 2012;Luong et al 2013), micromixer (Tofteberg et al 2010;Ait Mouheb et al 2011), and microreactor (Pohar et al 2012;Hardt et al 2005) and many more. In 1979, Terry et al has first reported a fabricated gas chromatography analyzer on silicon wafer (Terry et al 1979).…”