Applications of Polydopamine in Implant Surface Modification

Abstract

There is great clinical demand for orthopedic and dental implant surface modification methods to prevent osseointegration failure and improve implant biological functions. Notably, dopamine (DA) can be polymerized to form polydopamine (PDA), which is similar to the adhesive proteins secreted by mussels, to form a stable bond between the bone surface and implants. Therefore, PDA has the potential to be used as an implant surface modification material with good hydrophilicity, roughness, morphology, mechanical strength, biocompatibility, antibacterial activity, cellular adhesion, and osteogenesis. In addition, PDA degradation releases DA into the surrounding microenvironment, which is found to play an important role in regulating DA receptors on both osteoblasts and osteoclasts during the bone remodeling process. Furthermore, the adhesion properties of PDA suggest its use as an intermediate layer in assisting other functional bone remodeling materials, such as nanoparticles, growth factors, peptides, and hydrogels, to form “dual modifications.” The purpose of this review is to summarize the recent progress in research on PDA and its derivatives as orthopedic and dental implant surface modification materials and to analyze the multiple functions of PDA.

Antimicrobial properties and bonding durability of pH-responsive dentin adhesives with chlorhexidine-load mesoporous silica nanoparticles

“…In addition to CHX's antibacterial effectivity through gradual release, plydopamine has been suggested to exhibit contact bactericidal capacity via chelation with ions or proteins as well as electrostatic effects resulting from disruption of bacterial cell membranes (Ma et al, 2023). This dual mechanism may contribute to enhanced antibacterial action when combined with CHX.…”

Bioactive Materials for Disease Diagnosis and Therapy

“…Besides, highly crystalline HA produced at high temperatures is difficult to degrade, exhibits limited biological activity, and has relatively single structures . Currently, researchers have been focused on a bioinspired method to synthesize the HA coating to avoid these limitations (Ma et al, 2023).…”

Construction of functional surfaces for dental implants to enhance osseointegration

“…Besides, highly crystalline HA produced at high temperatures is difficult to degrade, exhibits limited biological activity, and has relatively single structures ( Zhao et al, 2020 ). Currently, researchers have been focused on a bioinspired method to synthesize the HA coating to avoid these limitations ( Ma et al, 2023 ).…”

“…The common bioinspired method used in HA-coated implants was the polydopamine (PDA)-assisted method ( Ma et al, 2023 ). It is a simple, mild but effective way to prepare HA-coated by the immersion of PDA-modified Ti into simulated body fluid (SBF).…”