Applications of quaternary ammonium compounds in the prevention and treatment of oral diseases: State-of-the-art and future directions

Li, Yiling; Li, Bolei; Guo, Xiao; Wang, Haohao; Cheng, Lei

doi:10.1016/j.jdent.2023.104678

Cited by 6 publications

(3 citation statements)

References 133 publications

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“…Their introduction to the dental field occurred in the 1970s, developed initially as mouthwashes to impede oral biofilm formation. Presently, antimicrobial QACs encompass monomeric QACs, gemini QACs, polymeric QACs, bola-amphiphilic salts, and those featuring two or more polar groups [ 115 ]. QACs exhibit notable efficacy against oral microorganisms such as S. mutans , S. gordonii , C. albicans , and E. faecalis [ 116 , 117 ], while also demonstrating potential in mitigating the development of drug resistance compared to antibiotics.…”

Section: Nanomaterials Used In Endodontics and Their Antimicrobial Me...mentioning

confidence: 99%

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Xiao,

Sun,

Huang

et al. 2024

Pharmaceutics

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Endodontic infections arise from the interactive activities of microbial communities colonizing in the intricate root canal system. The present study aims to update the latest knowledge of nanomaterials, their antimicrobial mechanisms, and their applications in endodontics. A detailed literature review of the current knowledge of nanomaterials used in endodontic applications was performed using the PubMed database. Antimicrobial nanomaterials with a small size, large specific surface area, and high chemical activity are introduced to act as irrigants, photosensitizer delivery systems, and medicaments, or to modify sealers. The application of nanomaterials in the endodontic field could enhance antimicrobial efficiency, increase dentin tubule penetration, and improve treatment outcomes. This study supports the potential of nanomaterials as a promising strategy in treating endodontic infections.

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Section: Nanomaterials Used In Endodontics and Their Antimicrobial Me...mentioning

confidence: 99%

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Xiao,

Sun,

Huang

et al. 2024

Pharmaceutics

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“…They also have stronger bactericidal activity than benzalkonium bromide and better killing effect on bacterial propagules and lipophilic viruses. Quaternary ammonium compounds have shown significant antibacterial effects against dental caries and periodontitis and some of them also have exhibited antiviral activity against coronaviruses, indicating their potential as treatments for COVID-19 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effective disinfecting of negative pressure pipelines of DCUs reduces the risk of cross infection in dental care

Lv,

Yan,

Han

et al. 2024

Journal of Oral Microbiology

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Objectives Microbial contamination of various accessory parts of the dental chair units (DCUs) is an essential source of cross infection, while the accessories of the crucial suction function are usually overlooked. In this study, we aim to find an effective disinfectant and a cost-effective method to remove bacterioplankton and bacterial biofilm deposited in the negative pressure suction pipelines to control cross infection during dental treatment. Methods Double-chain quaternary ammonium salt disinfectant (Orotol Plus®), 3% hydrogen peroxide solution plus multi-enzyme cleaning agent and chlorine disinfectant are used to clean and disinfect the negative pressure pipelines of DCUs. Microbiological examinations, air condition detection, corrosion tests and gene sequencing are performed. Results Little bacteria grow in the pipelines disinfected with double-chain quaternary ammonium salt disinfectants, destruction of biofilms in these pipelines appears, and multi-resistant bacteria cannot be detected. Minimal damage to metal sheets and fittings is caused by double-chain quaternary ammonium salt disinfectants. Conclusion Double-chain quaternary ammonium salt disinfectant has excellent bactericidal ability and anti-biofilm effect, and it is less corrosive to the fittings of the pipelines. Thus, the double-chain quaternary ammonium salt disinfectant is a potential novel disinfectant for negative pressure suction pipelines of DCUs to control cross infection during dental treatment. Clinical significance It is essential to add all these data to our dental practice to control cross infection with a broader landscape.

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“…Another concept of providing DCRMs with antimicrobial properties is based on the covalent incorporation of a monomeric biocide into the polymer network structure, constituting the DCRM matrix. It involves the copolymerization of universal dental dimethacrylates (DMAs), such as bisphenol A glycerolate dimethacrylate (Bis-GMA), its ethoxylated derivative (Bis-EMA), urethane-dimethacrylate monomer (UDMA), and triethylene glycol dimethacrylate (TEGDMA), with dimethacrylates having bioactive groups, of which dimethacrylates with quaternary ammonium (QA) groups (QADMAs) are the best known [18][19][20][21][22]. The QADMA content in a copolymer ranges from a few to several dozen percent.…”

Section: Introductionmentioning

confidence: 99%

Chemical Modification of Dental Dimethacrylate Copolymer with Tetramethylxylylene Diisocyanate-Based Quaternary Ammonium Urethane-Dimethacrylates—Physicochemical, Mechanical, and Antibacterial Properties

Drejka,

Chrószcz-Porębska,

Kazek-Kęsik

et al. 2024

Materials

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In this study, two novel quaternary ammonium urethane-dimethacrylates (QAUDMAs) were designed for potential use as comonomers in antibacterial dental composite restorative materials. QAUDMAs were synthesized via the reaction of 1,3-bis(1-isocyanato-1-methylethyl)benzene with 2-(methacryloyloxy)ethyl-2-decylhydroxyethylmethylammonium bromide (QA10+TMXDI) and 2-(methacryloyloxy)ethyl-2-dodecylhydroxyethylmethylammonium bromide (QA12+TMXDI). Their compositions with common dental dimethacrylates comprising QAUDMA 20 wt.%, urethane-dimethacrylate monomer (UDMA) 20 wt.%, bisphenol A glycerolate dimethacrylate (Bis-GMA) 40 wt.%, and triethylene glycol dimethacrylate (TEGDMA) 20 wt.%, were photocured. The achieved copolymers were characterized for their physicochemical and mechanical properties, including their degree of conversion (DC), glass transition temperature (Tg), polymerization shrinkage (S), water contact angle (WCA), flexural modulus (E), flexural strength (FS), hardness (HB), water sorption (WS), and water leachability (WL). The antibacterial activity of the copolymers was characterized by the minimum bactericidal concentration (MBC) and minimum inhibitory concentration (MIC) against Staphylococcus aureus and Escherichia coli. The achieved results were compared to the properties of a typical dental copolymer comprising UDMA 40 wt.%, Bis-GMA 40 wt.%, and TEGDMA 20 wt.%. The introduction of QAUDMAs did not deteriorate physicochemical and mechanical properties. The WS and WL increased; however, they were still satisfactory. The copolymer comprising QA10+TMXDI showed a higher antibacterial effect than that comprising QA12+TMXDI and that of the reference copolymer.

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Applications of quaternary ammonium compounds in the prevention and treatment of oral diseases: State-of-the-art and future directions

Cited by 6 publications

References 133 publications

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Nanoarchitectonics-Based Materials as a Promising Strategy in the Treatment of Endodontic Infections

Effective disinfecting of negative pressure pipelines of DCUs reduces the risk of cross infection in dental care

Chemical Modification of Dental Dimethacrylate Copolymer with Tetramethylxylylene Diisocyanate-Based Quaternary Ammonium Urethane-Dimethacrylates—Physicochemical, Mechanical, and Antibacterial Properties

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