Agents that alter the dynamics of hemostasis form an important part in management of conditions such as atherosclerosis, cerebrovascular disease, and bleeding diatheses. In this study, we explored the effects of heparin and tranexamic acid on the efficiency of blood coagulation. Using optical tweezers, we evaluated the pN-range micro-interaction between coagulating red blood cells (RBCs) by measuring the minimum power required to trap them. By observing the mobility of RBCs and the intensity of cellular interactions, we found that the coagulation process can be separated into three phases. The effects of heparin and tranexamic acid were examined by observing variations in cellular interaction during the coagulation phases. Heparin attenuated the interaction between RBCs and prolonged the first phase whereas the samples containing tranexamic acid bypassed the first two phases and immediately proceeded to the final one.
Agents that alter the dynamics of hemostasis form an important part in management of conditions such as atherosclerosis, cerebrovascular disease, and bleeding diatheses. In this study, we explored the effects of heparin and tranexamic acid on the efficiency of blood coagulation. Using optical tweezers, we evaluated the pN-range micro-interaction between coagulating red blood cells (RBCs) by measuring the minimum power required to trap them. By observing the mobility of RBCs and the intensity of cellular interactions, we found that the coagulation process can be separated into three phases. The effects of heparin and tranexamic acid were examined by observing variations in cellular interaction during the coagulation phases. Heparin attenuated the interaction between RBCs and prolonged the first phase whereas the samples containing tranexamic acid bypassed the first two phases and immediately proceeded to the final one.
“…The main objective of Task I -Device Fabrication is to engineer the appropriate carbon/polymer/metal cluster compositions which have electronic properties that are critically dependent on vibrations [1] or sxirface acoustic waves (SAW) [2]. A study was performed using the polymer poly(styrene-co-acrylonitrile) (PSA) and the metal gold (Au).…”
Section: Description Of Technical Research Progress a Au/psa Commentioning
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SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES)Office of Naval Research Regional Office Chicago 230 South Dearborn, Room 380 Chicago, IL 60604-1595
SPONSOR/MONITOR'S ACRONYM(S)
ONR
SPONSORING/MONITORING AGENCY REPORT NUMBERN/A
DISTRIBUTION AVAILABILITY STATEMENTApproved for Public Release; Distribution is Unlimited
SUPPLEMENTARY NOTESResearch in collaboration with Brewer Science, Inc. (Rolla, MO)
ABSTRACTThe goal of this project is to develop a new class of biosensors using carbon and polymer based microelectromechanical systems (MEMS). This interim report discusses the progress to date on the individual tasks outlined in the proposal. Progress has included a study to engineer the appropriate carbon/polymer/metal cluster compositions which have vibration sensitive electronic properties, initial imaging of structures created using microlithography and imaging of the carbon composite, biocompatible surface were done with SEM and AFM respectively. The methodology used for building antibody microan-ays to detect specific molecular binding events was demonstrated. Preliminary work on a prototype for an antigen collection system has been accomplished.
SUBJECT TERMS
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