Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body

Hoshino, Akihiro; Hanaki, Ken-Ichi; Suzuki, Kazuo; Yamamoto, Kenji

doi:10.1016/j.bbrc.2003.11.185

Cited by 256 publications

(179 citation statements)

References 27 publications

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“…During this process, nanoparticles are enclosed by early or late endosomes, within which it is, respectively, slightly acidic (pH 6.2-6.5) or pronouncedly acidic (pH 4.5-5.5). Under such an acidic microenvironment, some metallic nanoparticles, such as silver, 30 quantum dots, 31,32 and iron oxide nanoparticles, 33,34 may undergo dissolution and release metallic ions. Non-metallic nanoparticles, like mesoporous SiO 2 nanoparticles 35 may be also partially dissolved in cells or in vivo by this way.…”

Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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Nanotechnology is having a tremendous impact on our society. However, societal concerns about human safety under nanoparticle exposure may derail the broad application of this promising technology. Nanoparticles may enter the human body via various routes, including respiratory pathways, the digestive tract, skin contact, intravenous injection, and implantation. After absorption, nanoparticles are carried to distal organs by the bloodstream and the lymphatic system. During this process, they interact with biological molecules and perturb physiological systems. Although some ingested or absorbed nanoparticles are eliminated, others remain in the body for a long time. The human body is composed of multiple systems that work together to maintain physiological homeostasis. The unexpected invasion of these systems by nanoparticles disturbs normal cell signaling, impairs cell and organ functions, and may even cause pathological disorders. This review examines the comprehensive health risks of exposure to nanoparticles by discussing how nanoparticles perturb various physiological systems as revealed by animal studies. The potential toxicity of nanoparticles to each physiological system and the implications of disrupting the balance among systems are emphasized.

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Section: Absorption Distribution Metabolism and Excretion Of Nanopmentioning

confidence: 99%

Perturbation of physiological systems by nanoparticles

et al. 2014

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“…22 Similarly, CdSeZnS-MUA or CdSe/ZnS-SSA QDs at 400 µg/mL were reported to have no affect on the viability of Vero cells after 2 h. 23 In contrast, QD-induced cytotoxicity tends to be longer in nature, with exposure times up to 24 h required as previously mentioned. [17][18][19] In brief, we have described an online and continuous technique based on electric cell-substrate impedance sensing for measuring the concentration and time response function of fibroblastic V79 cells exposed to various nanoparticles including quantum dots and fluorescent gold nanoparticles. The half-inhibition concentration, the required concentration to achieve 50% inhibition, can be estimated from the response function to ascertain cytotoxicity during the course of the assay.…”

mentioning

confidence: 99%

Assessment of Cytotoxicity of Quantum Dots and Gold Nanoparticles Using Cell-Based Impedance Spectroscopy

et al. 2008

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A continuous online technique based on electric cellsubstrate impedance sensing (ECIS) was demonstrated for measuring the concentration and time response function of fibroblastic V79 cells exposed to nanomaterials such as quantum dots (QDs) and fluorescent gold nanoparticles. The half-inhibition concentration, (ECIS 50 ), the required concentration to attain 50% inhibition of the cytotoxic response, was estimated from the response function to ascertain cytotoxicity during the course of measurement. The ECIS 50 values agreed well with the results obtained using the standard neutral red assay. Cadmium selenide quantum dots showed direct cytoxicity with the ECIS assay. For the cadmium telluride quantum dots, significant toxicity could be assigned to free cadmium, although additional toxicity could be attributed to the QDs per se. The QDs synthesized with indium gallium phosphide and the fluorescent gold nanoparticles were not cytotoxic.

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“…Semiconductor quantum dots (QDs) such as ZnSe, ZnS and CdS, together with carbon dots, which have excellent photoluminescent properties, are also being used for imaging purposes (Hoshino et al 2004;Jaiswal et al 2004;Li & Zhu 2013). QD based fluorescence biosensors in particular have become very popular over the past two decades due to their high quantum yield, narrow and tunable emission spectrum and good photostability.…”

Section: Nanoparticles As Imaging and Contrast Enhancer Agentsmentioning

confidence: 99%

Nanomaterials for biomedical applications

Das

Mitra

Khurana

et al. 2013

Frontiers in Life Science

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Nanotechnology involves understanding and manipulating materials normally in the size range of 1 to 100 nm, where particles show completely novel physico-chemical properties from their bulk counterpart. In the last two decades a number of precisely engineered nanomaterials have been developed for diagnostic and therapeutic applications. For diagnostic applications, nanoparticles allow detection at the molecular scale. Some fluorescent nanohybrids can serve the dual purpose of detection and destruction of pathogenic microbes. The specificity and sensitivity of magnetic resonance imaging can be greatly improved by using nanoparticles as contrast enhancement material. As therapeutic agent, they allow targeted delivery and sustained release of drug molecules and they also have huge potential in tissue engineering. Given the vast range of application of nanomaterials in the biomedical domain, this review focuses on the major nanoparticle based diagnostic and therapeutic modalities.

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Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body

Cited by 256 publications

References 27 publications

Perturbation of physiological systems by nanoparticles

Perturbation of physiological systems by nanoparticles

Assessment of Cytotoxicity of Quantum Dots and Gold Nanoparticles Using Cell-Based Impedance Spectroscopy

Nanomaterials for biomedical applications

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