Applications of Tandem Mass Spectrometry: From Structural Analysis to Fundamental Studies

Madeira, Paulo J. Amorim; Florêncio, M. Helena

doi:10.5772/31736

Cited by 3 publications

(5 citation statements)

References 100 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Collision of compound can be performed in in single ionization cell or triple quadrupole system (TQS). TQS is the most frequently used now a day MS/MS techniques as compared to other mass analyzer [23].…”

Section: Tandem Mass Spectrometry (Ms/ms)mentioning

confidence: 99%

UPLC-MS: An Emerging Novel Technology and Its Application in Food Safety

Ashraf¹,

Nazir²,

Adnan³

et al. 2021

Analytical Chemistry - Advancement, Perspectives and Applications

View full text Add to dashboard Cite

Over the past decade, food safety has become an important issue worldwide due to higher incidences of food contamination. Currently, one of the great challenges in food safety is the analysis of emerging food contaminants. Moreover, the scope, relevance, and level of food safety and testing have never been in such complexity than in today's global marketplace. In recent years, a novel technology ultra performance liquid chromatography (UPLC) coupled with mass spectroscopy (MS) has been developed to estimate the food contaminants, as well as food components with better accuracy, sensitivity, precision, and high throughput. UPLC-MS works on van Deemter principle, which states that, the flow rate of smaller particles are much faster in compare with large particles as well as unfolding the correlation of flow rate and plate height. Additionally, various food components as well as food contaminants such as vitamins, amino acid, metabolite identification, adulteration, forensic testing, toxicity studies, phytoconstituents, pesticide in agricul ture, antibiotic residue, hormones, dyes and pigment analysis can be performed using UPLC-MS. Moreover, uniqueness of UPLC-MS and its wide range of application makes it an important tool for food safety laboratory around the world.

show abstract

Section: Tandem Mass Spectrometry (Ms/ms)mentioning

confidence: 99%

UPLC-MS: An Emerging Novel Technology and Its Application in Food Safety

Ashraf¹,

Nazir²,

Adnan³

et al. 2021

Analytical Chemistry - Advancement, Perspectives and Applications

View full text Add to dashboard Cite

show abstract

“…By changing the configurations of these analyzers, certain precursor ions can be selectively fragmented, providing valuable structural information. 1 An example of this technique is the product ion scan, where, on a QQQ instrument, the first quadrupole (Q1) selects a precursor ion of a specific mass and passes that ion to Q2, a collision cell where the ion is fragmented (by, for example, application of voltage and collision with an inert gas). The third quadrupole (Q3) then scans for the product ions (fragments) from this collision.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Tandem mass spectrometry (MS/MS) is a technique which uses two or more mass analyzers coupled together (e.g., the quadropoles of a triple quadrupole or QQQ instrument). By changing the configurations of these analyzers, certain precursor ions can be selectively fragmented, providing valuable structural information . An example of this technique is the product ion scan , where, on a QQQ instrument, the first quadrupole (Q1) selects a precursor ion of a specific mass and passes that ion to Q2, a collision cell where the ion is fragmented (by, for example, application of voltage and collision with an inert gas).…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometry Does Not Need to Be a “Grind”: Plant Secondary Metabolites in Coffee and Black Pepper as a Practical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Teaching Tool

Cinelli,

Wilson

2024

J. Chem. Educ.

View full text Add to dashboard Cite

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful analytical technique used in many disciplines. Therefore, teaching this technique in the undergraduate laboratory should involve practical data collection in a "realworld" application. For an upper division plant chemistry course, we developed a laboratory module of two experiments analyzing plant secondary metabolites in food and beverage products by LC-MS/MS. In the first, students use product ion scans and literature references to determine which chlorogenic acids (phenolic antioxidants), including which isomers, are present in coffee and hard cider. In the second experiment, students performed an untargeted analysis of peppercorn extract, examining the MS/MS fragmentation of the major alkamides (compounds responsible for pepper's pungency). Students then selected unknown alkamides, performed product ion scans, and proposed structures based on the observed fragments and losses. These experiments emphasize the utility of MS/MS for distinguishing closely related compounds, for making qualitative comparisons, and for proposing structures of unknown compounds. Both a pretest/post-test assessment and laboratory reports were used to assess learning outcomes related to MS/MS.

show abstract

“…Em um espectrômetro de massas do tipo triplo quadrupolo, além dos modos Full-Scan (varredura) e SIM (Single Ion Monitoring), as configurações utilizadas podem ser: monitoramento seletivo de reações (SRM, Selective Reaction Monitoring) ou monitoramento múltiplo de reações (MRM, Multiple Reaction Monitoring); varredura de íons produtos; varredura de íons precursores e varredura de perda neutra (Chiaradia et al, 2008;Hoffmann, 2007;Madeira;Florêncio, 2012).…”

Section: Cromatografia Gasosa Acoplada à Espectrometria De Massas Tandemunclassified

“…No Q3 acontece a varredura dos íons produzidos a partir da fragmentação do íon de interesse isolado em Q1 para obtenção do espectro de massas (Chiaradia et al, 2008;Hoffmann;Stroobant, 2007;Madeira;Florêncio, 2012).…”

Section: Cromatografia Gasosa Acoplada à Espectrometria De Massas Tandemunclassified

Desenvolvimento De Método Multiresíduo Em Gc-MS/MS E Lógica Fuzzy No Estudo De Pahs, Pcbs, Pbdes E Pesticidas Organoclorados E Sua Aplicação Em Sistemas Costeiros Do Brasil

GRIPP BOM AMORIM

View full text Add to dashboard Cite

show abstract

Applications of Tandem Mass Spectrometry: From Structural Analysis to Fundamental Studies

Cited by 3 publications

References 100 publications

UPLC-MS: An Emerging Novel Technology and Its Application in Food Safety

UPLC-MS: An Emerging Novel Technology and Its Application in Food Safety

Mass Spectrometry Does Not Need to Be a “Grind”: Plant Secondary Metabolites in Coffee and Black Pepper as a Practical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Teaching Tool

Desenvolvimento De Método Multiresíduo Em Gc-MS/MS E Lógica Fuzzy No Estudo De Pahs, Pcbs, Pbdes E Pesticidas Organoclorados E Sua Aplicação Em Sistemas Costeiros Do Brasil

Contact Info

Product

Resources

About