Applications of the Carrier Free Radioisotopes of Second Transition Series Elements in the Field of Nuclear Medicine

Mukhopadhyay, B.; Mukhopadhyay, Kakali

doi:10.4172/2155-9619.1000115

Cited by 16 publications

(9 citation statements)

References 66 publications

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“…The initial beam energy and intensity were adjusted by comparing the excitation functions of the 27 Al(p,x) 22,24 Na reactions, re-measured over the whole energy range studied, with the recommended values in the updated version of IAEA-TECDOC 1211 [17] (Fig. 1).…”

Section: Data Processingmentioning

confidence: 99%

“…The Al monitors foils were used for determination of the beam intensity and energy by remeasuring the excitation function for the 27 Al(p,x) 22,24 Na reactions at CYRIC over the entire covered energy range and comparing with recommended values (details in the next section). The target stacks were irradiated in a Faraday-cup like target holder at 24 nA for 30 min.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of activation cross sections of proton induced reactions on rhodium up to 70 MeV for practical applications

Tárkányi

Ditrói

Takács

et al. 2017

Nuclear Instruments and Methods in Physics Research Section B:

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Excitation functions were measured for the production of the 101,100 Pd, 102m, 102g,101m,101g,100,99m,99g Rh and 97 Ru radionuclides by bombardment of 103 Rh targets with proton beams up to 70 MeV, some of them for the first time. The new results are compared with the earlier experimental data and with the theoretical nuclear model code calculations from ALICE-IPPE, EMPIRE and TALYS 1.6. Thick target yields were deduced and possible application of the new data for production of medically relevant 101m,101g Rh and 97 Ru are discussed. Hermanne et al. [3] and Sudar et al. [13]). Yield data at low energies were reported by Dmitriev et al. [14]. Rhodium and rhodium alloys are used in fusion, fission technology and nuclear transmutation, where secondary high energy protons are induced. Reliable high energy experimental data are important for these applications.Nowadays medium energy accelerators were introduced in medical isotope production (cyclotrons and linear accelerators). Some radioisotopes can be produced only in this way and some others due to the smaller stopping power of high energy protons can be produced more effectively, compared to low energy accelerators. In present work the production of 97 Ru, 101m Rh and 101g Rh are the related isotopes. ExperimentalThe excitation functions for the 103 Rh(p,x) reactions were measured at the cyclotron of Tohoku University (CYRIC, Sendai, Japan) using the stacked foil technique. The experimental method was similar to the techniques used in our numerous earlier investigations of charged particle induced nuclear reactions for different applications. One stack was irradiated using 70 MeV incident proton energy. 103 Rh(p,pn) -9318.94 101m Rh 4.34 d 306.86 81 103 Rh(p,p2n) -16759.86

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Section: Data Processingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Investigation of activation cross sections of proton induced reactions on rhodium up to 70 MeV for practical applications

Tárkányi

Ditrói

Takács

et al. 2017

Nuclear Instruments and Methods in Physics Research Section B:

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“…Moreover, ruthenium element has a rich chemistry associated with its various oxidation states (II, III, IV and VIII) and forms more stable compounds compared to the SPECT-standard 99m Tc [4]. Many radioactive Ru-labeled compounds have been studied and found applications as summarized recently by [5], in particular as the chemotherapy agents [6,7].…”

Section: Introductionmentioning

confidence: 99%

New Cross-Sections for natMo(α,x) Reactions and Medical 97Ru Production Estimations with Radionuclide Yield Calculator

et al. 2019

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The production of 97Ru, a potential Single Photon Emission Computed Tomography (SPECT) radioisotope, was studied at ARRONAX. The cross-section of natMo(α,x)97Ru reaction was investigated in the range of 40–67 MeV irradiating the natMo and Al stacked-foils. The activities of 97Ru and other radioactive contaminants were measured via gamma spectroscopy technique. A global good agreement is observed between obtained cross-section results, previously reported values and TENDL-2017 predictions. Additionally, Radionuclide Yield Calculator, a software that we made available for free, dedicated to quickly calculate yields and plan the irradiation for any radioisotope production, was introduced. The yield of investigated nuclear reactions indicated the feasibility of 97Ru production for medical applications with the use of α beam and Mo targets opening the way to a theranostic approach with 97Ru and 103Ru.

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“…About 40% of the world population live in areas at risk of malaria transmission and P. falciparum is the ethiologic agent of malaria that causes more than 1 million deaths each year. According to the WHO 5 , there are 99 countries with active 8,9 .…”

Section: Introductionmentioning

confidence: 99%

The malarial infection can alter the normal biodistribution of a radiopharmaceutical?

Holanda

Barbosa²,

Rocha³

et al. 2015

J Surg Clin Res

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Objective: Infection with Plasmodium berghei is a model of murine malaria widely used in experimental studies, similar to Plasmodium falciparum in humans. The aim of this study was to investigate in vivo the influence of P. berghei infection on the biodistribution of sodium pertechnetate (Na 99m TcO 4 ) in mice. Methods: 14 Swiss mice were divided into two groups: control (n=7) and treated (n=7). Treated group were inoculated with 1x10 5 P. berghei infected red blood cells each. On the 15 th day, the infected group and the control group received 0.1 mL (0.66 MBq) of Na 99m TcO 4 . After 40 minutes, all animals were killed and kidney, liver, stomach and blood samples were isolated and the percentage of radioactivity per gram of tissue (%ATI/g) was determined. Parts of tissue samples were used for histological analysis. Data were compared by t-Student test and Mann-Whitney test, considering p<0.05 statistically significant. Results: No statistically significant difference in uptake of ATI%/g was observed in any of the organs. Statistically significant histological changes were seen in the liver of the infected group (cell vacuolization and necrosis) and in the kidney (alterations in the parietal cells and mesangial cells). Conclusions: Although the histopathological finding of necrosis has been a significant result, this change did not alter the uptake of technetium-99m at the site of infection. The parasitic infection by acute malaria or the degree of liver injury probably will not affect the performance of nuclear medicine examinations. The malarial infection can alter the normal biodistribution of a radiopharmaceutical? Holanda, CMC et al J Surg Cl Res -Vol. 5 (2) 2014:69-79 70 RESUMO Objetivo: A infecção por Plasmodium berghei é um modelo murino de malária amplamente utilizado em estudos experimentais, semelhante ao de Plasmodium falciparum nos seres humanos. Este estudo objetivou investigar in vivo a influência da infecção pelo P. berghei na biodistribuição do pertecnetato de sódio (NaTc 99m O 4 ) em camundongos. Métodos: 14 camundongos suiços foram divididos em dois grupos: controle (n=7) e tratado (n=7). O grupo tratado foi inoculado com 1x10 5 hemácias saguineas infectadas por P. Berghei. No 15º dia, o grupo infectado e o grupo controle receberam 0,1 mL (0,66 MBq) de NaTc 99m O 4 . Após 40 minutos, os animais foram sacrificados e amostras de rim, fígado, estômago e sangue foram isolados e a percentagem de radioatividade por grama de tecido (% ATI/g) foi determinada. Amostras dos tecidos foram também utilizadas para análise histológica. Os dados foram comparados pelo teste t de Student e Mann-Whitney, considerando-se p<0,05 estatisticamente significativo. Resultados: não houve diferença estatisticamente significativa na captação do %ATI/g em nenhum dos órgãos estudados. Alterações histológicas estatisticamente significativas foram observadas no fígado do grupo infectado (vacuolização celular e necrose) e no rim (alterações nas células parietais e células mesangiais). Conclusões: Embora o achado histopatológi...

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Applications of the Carrier Free Radioisotopes of Second Transition Series Elements in the Field of Nuclear Medicine

Cited by 16 publications

References 66 publications

Investigation of activation cross sections of proton induced reactions on rhodium up to 70 MeV for practical applications

Investigation of activation cross sections of proton induced reactions on rhodium up to 70 MeV for practical applications

New Cross-Sections for natMo(α,x) Reactions and Medical 97Ru Production Estimations with Radionuclide Yield Calculator

The malarial infection can alter the normal biodistribution of a radiopharmaceutical?

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