Applications of the Montmorillonites in Tablet Making

Wai, Kee-Neng; DeKay, H. George; Banker, Gilbert S.

doi:10.1002/jps.2600551116

Cited by 31 publications

(8 citation statements)

References 5 publications

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“…Bioavailability of drugs is reported to be influenced by stabilizing agents used in their formulations [11]. Aluminum-magnesium silicate (AMS) is used to stabilize drugs [12,13]. Also, molecules of AMS are reported to be composed of platelets that are only 0.96 nm thick [13].…”

Section: Development Of Resistance Against Drugs By Bacteriamentioning

confidence: 99%

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

Ezeibe¹,

Ezeobele²,

Esen³

et al. 2013

Health

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To treat resistant Escherichia coli infection in chicks, Ampicillin was stabilized with a synthetic aluminum-magnesium silicate (AMS) to prolong its bioavailability. Its dose was also reduced to minimize adverse side effects. Vitamins A, C, E and Selenium levels in the chicks' feeds were increased to enhance immune response of the chicks. E. coli coloning forming units, per ml of bile of the chicks, treated with Ampicillin and with Ampicillin in AMS, were: 228800.00 ± 90103.50 and 134500.00 ± 44937.97 at 10 mg/kg, 104400.00 ± 36024.44 and 34800.00 ± 8014.97 at 7.5 mg/kg, 198400.00 ± 129301.80 and 156800.00 ± 109392.70 at 5 mg/kg. Mean bacterial loads of the untreated groups, fed normal feed and those fed the fortified feed were 824400.00 ± 322424.80 and 534800.00 ± 277832.80. At 7.5 mg/kg. Ampicillin in the AMS, effectively (P < 0.05) treated resistant E. coli infection in chicks, fed immunestimulants, with the infection rate reduced by 95.8%.

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Section: Development Of Resistance Against Drugs By Bacteriamentioning

confidence: 99%

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

Ezeibe¹,

Ezeobele²,

Esen³

et al. 2013

Health

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“…The presence of the clays in these pharmaceutical formulations affects the drug activity because of its interactions with the clay [1]. Interactions between clay minerals and drugs may increase or decrease the bioavailability of drug after administration [1][2][3]. Promethazine is a cationic drug which possesses high solubility in water.…”

Section: Introductionmentioning

confidence: 99%

Equilibrium and kinetics for the sorption of promethazine hydrochloride onto K10 montmorillonite

Gereli

Seki

Kusoglu

et al. 2006

Journal of Colloid and Interface Science

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“…The montmorillonite is classified either as sodium montmorillonite (NaM) or calcium montmorillonite (CaM) on the basis of dominant interlayer cation being Na + or Ca 2+ . Bentonites containing NaM as the major clay mineral have relatively high swelling and gelling properties (Luckham & Rossi, 1999), which are the basic pharmacopeia requirements (US Pharmacopeia, 2007a) and are also important for particular pharmaceutical use such as suspending and tablet disintegrate agents (Wai et al, 1966;Fielden, 1996;Viseras et al, 2001;Lopez-Galindo et al, 2007).…”

mentioning

confidence: 99%

Preparation and characterization of purified Na-activated bentonite from Karak (Pakistan) for pharmaceutical use

Shah¹,

Khattak²,

Valenzuela³

et al. 2013

Clay miner.

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AB ST R ACT : The purpose of this paper was to prepare purified Na-bentonite with improved properties for use in the pharmaceutical industry. Calcium bentonite from the Shagia region of Karak district, Pakistan, was activated with various proportions of sodium carbonate (2, 3, 5 and 8 wt.%) and purified by sedimentation to remove impurities, especially quartz. X-ray diffraction (XRD), and swelling volume confirmed the conversion of raw bentonite to sodium bentonite by using 5% Na 2 CO 3 . The sodium bentonite (K5) obtained by activation met the chemical and microbiological requirements set by the pharmacopeias regarding the toxic trace elemental content (Pb and As), absence of E. coli, total aerobic microbial contents and physicochemical properties such as swelling volume, pH and sedimentation volume. Therefore K5 bentonite could be designated as potentially suitable for pharmaceutical applications. The CEC, surface area, porosity, pH, gel formation and swelling volume indicated that K5 bentonite could be used in the formulation of oral suspension and in topical application.

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Applications of the Montmorillonites in Tablet Making

Cited by 31 publications

References 5 publications

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

Equilibrium and kinetics for the sorption of promethazine hydrochloride onto K10 montmorillonite

Preparation and characterization of purified Na-activated bentonite from Karak (Pakistan) for pharmaceutical use

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Applications of the Montmorillonites in Tablet Making

Cited by 31 publications

References 5 publications

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant &lt;i&gt;Escherichia coli&lt;/i&gt; infection

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant &lt;i&gt;Escherichia coli&lt;/i&gt; infection

Equilibrium and kinetics for the sorption of promethazine hydrochloride onto K10 montmorillonite

Preparation and characterization of purified Na-activated bentonite from Karak (Pakistan) for pharmaceutical use

Contact Info

Product

Resources

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Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection

Synergy in antibacterial activities of Ampicillin trihydrate, stabilized with a synthetic aluminum-magnesium silicate and immune-stimulants, on resistant <i>Escherichia coli</i> infection