Applications of TMS in individuals with methamphetamine use disorder: A review

Zhang, Mingming; Chen, Lei; Ren, Ziwei; Wang, Zhiyan; Luo, Wenbo

doi:10.1016/j.heliyon.2024.e25565

Cited by 1 publication

(1 citation statement)

References 83 publications

(80 reference statements)

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“…This study employed a computational modeling approach to elucidate the decision-making psychological mechanisms underlying rTMS intervention on patients with MUD. Consistent with prior research [ 50 – 53 ], rTMS treatment targeting the left dlPFC resulted in decreased self-reported craving among MUD patients. A recent study demonstrated that changes in EEG microstates in patients with MUD were linked to a reduction in craving levels after receiving rTMS [ 54 ].…”

Section: Discussionsupporting

confidence: 88%

Modulation of dlPFC function and decision-making capacity by repetitive transcranial magnetic stimulation in methamphetamine use disorder

Liu,

Cui,

et al. 2024

Transl Psychiatry

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This study explores the impact of repetitive transcranial magnetic stimulation (rTMS) on decision-making capabilities in individuals with methamphetamine use disorder (MUD), alongside potential underlying psychological mechanisms. Employing the Iowa Gambling Task (IGT) and computational modeling techniques, we assessed the decision-making processes of 50 male MUD participants (24 underwent rTMS treatment, 26 received no treatment) and 39 healthy controls (HC). We compared pre- and post-rTMS treatment alterations in the left dorsolateral prefrontal cortex (dlPFC). Results revealed inferior performance in the IGT among the MUD group, characterized by aberrant model parameters in the Value-Plus-Perseverance (VPP) model, including heightened learning rate, outcome sensitivity, and reinforcement learning weight, alongside diminished response consistency and loss aversion. RTMS treatment demonstrated efficacy in reducing craving scores, enhancing decision-making abilities, and partially restoring normalcy to certain model parameters in the MUD cohort. Nonetheless, no linear relationship between changes in model parameters and craving was observed. These findings lend support to the somatic marker hypothesis, implicating the dlPFC in the decision-making deficits observed in MUD, with rTMS potentially ameliorating these deficits by modulating the function of these brain regions. This study not only offers novel insights and methodologies for MUD rehabilitation but also underscores the necessity for further research to corroborate and refine these findings. Trial Registration www.chictr.org.cn Identifier: No. ChiCTR17013610.

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Section: Discussionsupporting

confidence: 88%