Applications of Transcranial Doppler Ultrasonography in Sickle Cell Disease, Stroke, and Critical Illness in Children

LaRovere, Kerri L.; O’Brien, Nicole

doi:10.1007/978-3-030-96893-9_19

Cited by 1 publication

(1 citation statement)

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“…Several studies amplify the significance of TCD in unveiling thromboembolic occurrences in MMD. Since the 1980s, TCD has been entrenched as a methodological approach for screening individuals with sickle cell disease and Moyamoya syndrome, particularly regarding the necessity for blood transfusions as a primary stroke preventative strategy[ 23 ]. It has also been propounded that TCD could be potentially efficacious for screening asymptomatic Moyamoya patients to discern the necessity for antiplatelet treatment as a preemptive measure against stroke.…”

Section: Antithrombotic Management In MMDmentioning

confidence: 99%

Is medical management useful in Moyamoya disease?

Muengtaweepongsa,

Panpattanakul

2024

World J Clin Cases

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Moyamoya disease (MMD), characterized by progressive internal carotid artery stenosis and collateral vessel formation, prompts cerebral perfusion complications and is stratified into idiopathic and Moyamoya syndrome subtypes. A multifaceted approach toward MMD management addresses cerebral infarctions through revascularization surgery and adjunctive medical therapy, while also navigating risks such as intracranial hemorrhage and cerebral infarction resulting from arterial stenosis and fragile collateral vessels. Addressing antithrombotic management reveals a potential role for treatments like antiplatelet agents and anticoagulants, despite the ambiguous contribution of thrombosis to MMD-related infarctions and the critical balance between preventing ischemic events and averting hemorrhagic complications. Transcranial doppler has proven useful in thromboembolic detection, despite persisting challenges concerning the efficacy and safety of antithrombotic treatments. Furthermore, antihypertensive interventions aim to manage blood pressure meticulously, especially during intracerebral hemorrhage, with recommendations and protocols varying based on the patient’s hypertension status. Additionally, lipid-lowering therapeutic strategies, particularly employing statins, are appraised for their possible beneficial role in MMD management, even as comprehensive data from disease-specific clinical trials remains elusive. Comprehensive guidelines and protocols to navigate the multifaceted therapeutic avenues for MMD, while maintaining a delicate balance between efficacy and safety, warrant further meticulous research and development. This protocol manuscript seeks to elucidate the various aspects and challenges imbued in managing and navigating through the complex landscape of MMD treatment.

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Section: Antithrombotic Management In MMDmentioning

confidence: 99%