Applications of upconversion nanoparticles in cellular optogenetics

Lin, Yinyan; Yao, Yuanfa; Zhang, Wanmei; Fang, Qiuyu; Zhang, Luhao; Zhang, Yan; Xu, Yingke

doi:10.1016/j.actbio.2021.08.035

Cited by 29 publications

(22 citation statements)

References 92 publications

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“…Also, the versatility offered by sharp emission bands and spectral tuning enables multiplexing. All these advantages of UCNPs have led into their use in altering the neural cell activity in vitro and living (and awake) mice with the use of both implantable and targeting molecule functionalized UCNP probes. − ,− More details are already discussed in section .…”

Section: Emerging Applications Of Ucnpsmentioning

confidence: 99%

“…The field of optogenetics is an emerging area that aims to make use of light to stimulate a genetically defined light-sensitive ion channel in a spatiotemporally controlled manner for manipulating a targeted neural activity in the brain of living organisms. , Conventional irradiation techniques (using light <600 nm wavelength) suffer from poor penetration depth in biological tissues, limiting their practical use for neuronal modulation in vivo . The use of UCNPs can overcome these limitations by providing improved penetration depths of light (up to 1 cm) and reduced local heating, thereby enabling optogenetic-based modulation even in deeper regions of the brain.…”

Section: Emerging Applications Of Ucnpsmentioning

confidence: 99%

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Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications

Malhotra

Hrovat

Kumar

et al. 2023

ACS Appl. Mater. Interfaces

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Lanthanide-doped upconversion nanoparticles (UCNPs) possess the remarkable ability to convert multiple near-infrared (NIR) photons into higher energy ultraviolet−visible (UV−vis) photons, making them a prime candidate for several advanced applications within the realm of nanotechnology. Compared to traditional organic fluorophores and quantum dots (QDs), UCNPs possess narrower emission bands (fwhm of 10−50 nm), large anti-Stokes shifts, low toxicity, high chemical stability, and resistance to photobleaching and blinking. In addition, unlike UV−vis excitation, NIR excitation is nondestructive at lower power intensities and has high tissue penetration depths (up to 2 mm) with low autofluorescence and scattering. Together, these properties make UCNPs exceedingly favored for advanced bioanalytical and theranostic applications, where these systems have been well-explored. UCNPs are also well-suited for bioimaging, optically modulating chemistries, forensic science, and other state-of-the-art research applications. In this review, an up-to-date account of emerging applications in UCNP research, beyond bioanalytical and theranostics, are presented including optogenetics, super-resolution imaging, encoded barcodes, fingerprinting, NIR vision, UCNP-assisted photochemical manipulations, optical tweezers, 3D printing, lasing, NIR-II imaging, UCNP-molecule nanohybrids, and UCNP-based persistent luminescent nanocrystals.

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Section: Emerging Applications Of Ucnpsmentioning

confidence: 99%

Section: Emerging Applications Of Ucnpsmentioning

confidence: 99%

Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications

Malhotra

Hrovat

Kumar

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…NIR optogenetic stimulation offers the possibility of delivering light to deep brain regions, is less invasiveness, and has a high spatial resolution and cell specificity (Chen S. et al, 2020 ). Compared with optogenetics, NIR optogenetic stimulation can be manipulated remotely in the brain without resulting in behavior restriction (All et al, 2019 ; Lin et al, 2021 ). This approach has been validated in vitro and in vivo in terms of its capability to modulate neural activities, and the results suggested potential neuroscience applications.…”

Section: Near-infrared Optogenetic Stimulationmentioning

confidence: 99%

Review of Noninvasive or Minimally Invasive Deep Brain Stimulation

Liu

Qiu

Hou

et al. 2022

Front. Behav. Neurosci.

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Brain stimulation is a critical technique in neuroscience research and clinical application. Traditional transcranial brain stimulation techniques, such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS) have been widely investigated in neuroscience for decades. However, TMS and tDCS have poor spatial resolution and penetration depth, and DBS requires electrode implantation in deep brain structures. These disadvantages have limited the clinical applications of these techniques. Owing to developments in science and technology, substantial advances in noninvasive and precise deep stimulation have been achieved by neuromodulation studies. Second-generation brain stimulation techniques that mainly rely on acoustic, electronic, optical, and magnetic signals, such as focused ultrasound, temporal interference, near-infrared optogenetic, and nanomaterial-enabled magnetic stimulation, offer great prospects for neuromodulation. This review summarized the mechanisms, development, applications, and strengths of these techniques and the prospects and challenges in their development. We believe that these second-generation brain stimulation techniques pave the way for brain disorder therapy.

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“…There are five types of upconversion luminescence (UCL) mechanisms ( Figure 2B ) of upconversion nanoparticles: 1) excited-state absorption (ESA), 2) energy looping/photon avalanche (PA), 3) energy transfer upconversion (ETU), 4) cooperative sensitization (CS), and 5) energy migration upconversion (EMU). Notably, PA is rarely found in lanthanide materials ( Lin et al, 2021 ).…”

Section: Upconversion Luminescence Mechanismsmentioning

confidence: 99%

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

Liu²,

Wang³

et al. 2022

Front. Chem.

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Major medical advances in antibiotics for infectious diseases have dramatically improved the quality of life and greatly increased life expectancy. Nevertheless, the widespread and inappropriate exploitation of antibacterial agents has resulted in the emergence of multi-drug-resistant bacteria (MDR). Consequently, the study of new drugs for the treatment of diseases associated with multi-drug-resistant bacteria and the development of new treatments are urgently needed. Inspiringly, due to the advantages of a wide antimicrobial spectrum, fast sterilization, low resistance, and little damage to host tissues and normal flora, antibacterial photodynamic therapy (APDT), which is based on the interaction between light and a nontoxic photosensitizer (PS) concentrated at the lesion site to generate reactive oxygen species (ROS), has become one of the most promising antibacterial strategies. Recently, a burgeoning APDT based on a variety of upconversion nanoparticles (UCNPs) such as PS and near-infrared (NIR) light has been fully integrated in antibacterial applications and achieved excellent performances. Meanwhile, conjugated nanoparticles have been frequently reported in UCNP design, including surface-modified PS conjugates, antibiotic-PS conjugates, and dual or multiple antibacterial modal PS conjugates. This article provides an overview of the state-of-the-art design and bactericidal effects of UCNPs and their based APDTs. The first part discusses the design and mechanisms for UCNPs currently implemented in biomedicine. The second part focuses on the applications and antimicrobial effects of diverse APDT based on UCNPs in antibacterial-related infectious diseases.

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Applications of upconversion nanoparticles in cellular optogenetics

Cited by 29 publications

References 92 publications

Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications

Lanthanide-Doped Upconversion Nanoparticles: Exploring A Treasure Trove of NIR-Mediated Emerging Applications

Review of Noninvasive or Minimally Invasive Deep Brain Stimulation

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

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