Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Borse, Shraddha; Rafique, Rafia; Murthy, Z.V.P.; Park, Tae Jung; Kailasa, Suresh Kumar

doi:10.1039/d1an02170b

Cited by 48 publications

(34 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, nanoparticle size also has a great effect on the material. Smaller UCNPs have higher endocytosis efficiency but also possibly reduce UCL efficiency ( Borse et al, 2022 ). Ultrasmall-sized (such as < 5 nm) UCNPs have poor UCL efficiency.…”

Section: Limitations For Upconversion Nanoparticle-based Antibacteria...mentioning

confidence: 99%

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

Liu²,

Wang³

et al. 2022

Front. Chem.

View full text Add to dashboard Cite

Major medical advances in antibiotics for infectious diseases have dramatically improved the quality of life and greatly increased life expectancy. Nevertheless, the widespread and inappropriate exploitation of antibacterial agents has resulted in the emergence of multi-drug-resistant bacteria (MDR). Consequently, the study of new drugs for the treatment of diseases associated with multi-drug-resistant bacteria and the development of new treatments are urgently needed. Inspiringly, due to the advantages of a wide antimicrobial spectrum, fast sterilization, low resistance, and little damage to host tissues and normal flora, antibacterial photodynamic therapy (APDT), which is based on the interaction between light and a nontoxic photosensitizer (PS) concentrated at the lesion site to generate reactive oxygen species (ROS), has become one of the most promising antibacterial strategies. Recently, a burgeoning APDT based on a variety of upconversion nanoparticles (UCNPs) such as PS and near-infrared (NIR) light has been fully integrated in antibacterial applications and achieved excellent performances. Meanwhile, conjugated nanoparticles have been frequently reported in UCNP design, including surface-modified PS conjugates, antibiotic-PS conjugates, and dual or multiple antibacterial modal PS conjugates. This article provides an overview of the state-of-the-art design and bactericidal effects of UCNPs and their based APDTs. The first part discusses the design and mechanisms for UCNPs currently implemented in biomedicine. The second part focuses on the applications and antimicrobial effects of diverse APDT based on UCNPs in antibacterial-related infectious diseases.

show abstract

Section: Limitations For Upconversion Nanoparticle-based Antibacteria...mentioning

confidence: 99%

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

Liu²,

Wang³

et al. 2022

Front. Chem.

View full text Add to dashboard Cite

show abstract

“…Up-conversion luminescence is an anti-Stokes process that converts invisible infrared light into visible light, making it valuable for various applications such as infrared detection, 1,2 stereo imaging, [3][4][5][6] biomedicine, etc. [7][8][9] The current research on up-conversion in the near-infrared band has primarily focused on the 808 nm and 980 nm bands, [10][11][12] while relatively little research has been focused on the 1550 nm band. This is primarily because Nd 3+ and Yb 3+ ions can be used as sensitizer ions in the 808 nm and 980 nm bands, respectively, to enhance the up-conversion luminescence of the samples.…”

Section: Introductionmentioning

confidence: 99%

Co-doping of Ho–Yb ion pairs modulating the up-conversion luminescence properties of fluoride phosphors under 1550 nm excitation

Lei¹,

Lü²,

Sun³

et al. 2023

Dalton Trans.

View full text Add to dashboard Cite

show abstract

“…19 In terms of luminescent materials, traditional luminescent agents are usually harmful to cells and prone to quenching. 20,21 Rare earth ion upconversion (UC) luminescent materials excited by near-infrared (NIR) light can avoid these issues, minimize auto-luminescence from biological tissues, and penetrate tissues to a greater extent with acceptable biocompatibility. 21,22 Moreover, the direct interactions be- tween magnetic and luminescent materials remarkably reduce the performance of each component, especially the luminescent intensity, which is not conducive to tracing.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Red Blood Cell-Mimicking Janus Microparticles with Enhanced Upconversion Luminescence and Drug Delivery Performance Using Double-Needle Electrospray

Cui

et al. 2023

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

The shape and function of micro-/nano-particles for loading drugs play an important role in the transportation process of the drug delivery system. This study successfully fabricated red blood cell (RBC)-mimicking Janus microparticles (JMPs) using doubleneedle electrospray, which contained porous Fe 3 O 4 magnetic nanoparticles (MNPs) and upconversion (UC) luminescent nanoparticles NaYF 4 :Yb 3+ ,Er 3+ and exhibited a unique two-compartment structure. The JMPs possessed excellent magnetic and UC luminescent properties, as well as good hemocompatibility and cellular compatibility. Importantly, the two compartments of the Janus structure significantly enhanced the UC luminescent intensity compared to single compartment microparticles by reducing direct interactions between Fe 3 O 4 MNPs and UC luminescent materials. By utilizing the porous structure of Fe 3 O 4 MNPs, doxorubicin hydrochloride was loaded into Fe 3 O 4 MNPs and then embedded into the JMPs resulting in a slow-release effect. Given the excellent properties of magnetic and UC luminescence, biocompatibility, and drug slow-release ability, the RBC-mimicking JMPs have significant potential for drug delivery and bioimaging applications.

show abstract

Applications of upconversion nanoparticles in analytical and biomedical sciences: a review

Abstract: Lanthanide-doped upconversion nanoparticles (UCNPs) have gained more attention from researchers due to their unique properties of photon conversion from an excitation/ incident wavelength to a more suitable emission wavelength at...

Cited by 48 publications

References 123 publications

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

Upconversion nanoparticles and its based photodynamic therapy for antibacterial applications: A state-of-the-art review

Co-doping of Ho–Yb ion pairs modulating the up-conversion luminescence properties of fluoride phosphors under 1550 nm excitation

Fabrication of Red Blood Cell-Mimicking Janus Microparticles with Enhanced Upconversion Luminescence and Drug Delivery Performance Using Double-Needle Electrospray

Contact Info

Product

Resources

About