In this chapter, the reader is introduced to the topic of driver distraction: its definition and mechanisms; its impact on driving performance and safety; approaches to preventing it; evidence-based injury prevention and mitigation countermeasures; and new frames of reference for conceptualizing distraction as traditional driving functions and tasks become increasingly automated. Some strategies that might be considered by societal stakeholders in setting a coordinated agenda for the management of distracted driving going into the future are also presented. Until all vehicles can safely drive themselves, in all conditions, all of the time, it is unlikely that, for driver distraction, Vision Zero will be achieved. In the meantime, however, there is much that can be done to slow its spread and mitigate it effects.