Wang et al.'s (2024) article is relevant due to several reasons. The obvious is previous work's replication and expansion (Djebbara et al., 2019(Djebbara et al., , 2021 by exploring how different forms of movement (walking/keyboard press) and environments (2D/3D) affect affordance perception. Replication and expansion of experimental effects using diverse populations and contexts is highly relevant to the still fledgling fields of mobile brain/body imaging (MoBI) and neuroarchitecture; it should be facilitated and encouraged. Furthermore, their study implements a scalable experimental design (SED; Parada, 2018) across multiple articles (Djebbara et al., 2019(Djebbara et al., , 2021Wang et al., 2024), which is particularly relevant for applied neuroscience.In addition to providing insights into how natural, built, digital, and symbolic (NaBDS) environments impact cognition from the perspective of 4E-Cognition, 1 this commentary also seeks to bridge the gap between MoBI and the microbiome of the built environment (MoBE), which is a relevant aspect of 4E-Cognition (Palacios-García et al., 2022). By furthering the integration of these two frameworks (Palacios-García et al., 2022;Palacios-García & Parada, 2021), we aim to propose actionable steps that merge the physiological and microbial aspects of human-environment interactions. This integration emphasizes the need for evidence-based design features that promote both cognitive and microbial health in NaBDS environments.Even though we promote the 3E-Cognition 2 principles for applied neuroscience (e.g. neuroarchitecture; Parada et al., 2024), here we will nevertheless contextualize Wang et al.'s findings within the broader perspective offered by 4E-Cognition (Figure 1).