Applied investigation of person-specific and context-specific factors on postoperative recovery and clinical outcomes of patients undergoing gastrointestinal cancer surgery: multicentre European study

Abstract

IntroductionCancer treatments have greatly advanced over the past two decades causing survival improvements and reduced complications from cancer surgery. However, the cancer diagnosis and the effects of treatment modalities pose a major risk to patients' psychological well-being. Given current interest and emerging evidence about the importance of psychological and social factors on cancer survival and coping with cancer treatments, this study will build and expand research in order to identify key modifiable psychosocial variables that contribute to better physical and mental health following gastrointestinal cancer (GIC) surgery.ObjectivesTo elucidate the incidence of postoperative psychiatric morbidity within 6 months following GIC surgery. To identify key measurable modifiable preoperative psychological factors that can significantly affect postoperative psychiatric morbidity in patients undergoing surgery for GIC. To clarify the changes seen in a patient's psychological well-being during their treatment pathway for GIC.Methods and analysisThis multicentre study has an observational longitudinal study design. In total, 1000 patients will be screened with a multicomponent psychological questionnaire at four different time points: at diagnosis, preoperatively, 1 and 6 months after surgery. Data from this questionnaire will be linked to postoperative complications including psychiatric morbidity, length of hospital stay and recovery to normal activity.Ethics and disseminationNHS Health Research Authority approval was gained on (REC reference 15.LO/1847) for the completion of this study. Multiple platforms will be used for the dissemination of the research data, including international clinical and patient group presentations and publication of research outputs in a high impact clinical journal.

Psychological support of esophageal cancer patient?

“…EC is associated with poor prognosis and significant impact on patients' habits and wellbeing. Overall, cancer diagnosis and treatment deeply affect both physical and psychological status (1)(2)(3)(4)(5). Patient commonly experience high levels of stress and anxiety, depressive and psychosomatic symptoms (1).…”

“…Overall, cancer diagnosis and treatment deeply affect both physical and psychological status (1)(2)(3)(4)(5). Patient commonly experience high levels of stress and anxiety, depressive and psychosomatic symptoms (1). The direct consequences of this psychological imbalance may be the adoption of maladaptive coping strategies (1,(6)(7)(8) that are associated with poor clinical and survival outcomes (9)(10)(11)(12).…”

“…Patient commonly experience high levels of stress and anxiety, depressive and psychosomatic symptoms (1). The direct consequences of this psychological imbalance may be the adoption of maladaptive coping strategies (1,(6)(7)(8) that are associated with poor clinical and survival outcomes (9)(10)(11)(12). In patients with lung cancer, an increased risk of mortality has been related to depression (12), which may arise in around 40% of cancer patients (13).…”

Perioperative Risk Factors of Psychological Distress in Patients Undergoing Treatment for Esophageal Cancer

“…These perioperative psychological distresses may lead to discontinuation of additional chemotherapy or chemo-radiotherapy after surgery. Moreover, a recent study identi ed a link between psychological state of anxiety or depression and an increased risk of death from cancer [5][6][7]. We described the relationship between psychological distress and HRQOL on each points of the treatment of esophageal cancer in the past report [6].…”

“…Moreover, a recent study identi ed a link between psychological state of anxiety or depression and an increased risk of death from cancer [5][6][7]. We described the relationship between psychological distress and HRQOL on each points of the treatment of esophageal cancer in the past report [6]. In this past study, we analysed risk factors of psychological distress "on each point of the treatment".…”