Applied Pathophysiology of Blast Injuries

Moloney, John; Welch, Mark; Cardinal, Alexandra

doi:10.33553/jhtam.v1i1.20

Cited by 2 publications

(2 citation statements)

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“…Literature of experiments performed to investigate spalling within the brain is limited. Rather, existing literature of spalling in biological systems primarily focuses in air containing organs like the lung and bowel (17,18). Further, more recent work suggests that spalling may not be as likely for a blast-brain interaction when compared with gas containing organ systems.…”

Section: Review Scope and Rationalementioning

confidence: 99%

“…As such, the cavitation bubble collapse-related findings discussed later in this review can be cross-applied to the discussion of implosion. However, like spalling, the literature shows that implosion is more likely to occur in the gas containing organ systems (18). Implosion is inherently discussed in section 2.2 since collapse of existing nanobubbles within the brain may be considered as implosion, rather than cavitation.…”

Section: Review Scope and Rationalementioning

confidence: 99%

See 1 more Smart Citation

Cerebrospinal Fluid Cavitation as a Mechanism of Blast-Induced Traumatic Brain Injury: A Review of Current Debates, Methods, and Findings

Marsh

Bentil

2021

Front. Neurol.

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Cavitation has gained popularity in recent years as a potential mechanism of blast-induced traumatic brain injury (bTBI). This review presents the most prominent debates on cavitation; how bubbles can form or exist within the cerebrospinal fluid (CSF) and brain vasculature, potential mechanisms of cellular, and tissue level damage following the collapse of bubbles in response to local pressure fluctuations, and a survey of experimental and computational models used to address cavitation research questions. Due to the broad and varied nature of cavitation research, this review attempts to provide a necessary synthesis of cavitation findings relevant to bTBI, and identifies key areas where additional work is required. Fundamental questions about the viability and likelihood of CSF cavitation during blast remain, despite a variety of research regarding potential injury pathways. Much of the existing literature on bTBI evaluates cavitation based off its prima facie plausibility, while more rigorous evaluation of its likelihood becomes increasingly necessary. This review assesses the validity of some of the common assumptions in cavitation research, as well as highlighting outstanding questions that are essential in future work.

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Section: Review Scope and Rationalementioning

confidence: 99%

Section: Review Scope and Rationalementioning

confidence: 99%