Under the background of double circulation, the national logistics hub will play an important role of node, hub and platform in the national logistics network. As a national strategy, the integration of Yangtze River Delta matters a lot to the national logistics network. This study constructs the evaluation index system of national logistics hubs and studies the construction of national logistics hubs in Yangtze River Delta and central China based on DPSIR theory. DPSIR model integrates the advantages of pressure-state-response (PSR) model and driving-state-response (DSR) model, and evaluates from driving force, pressure, state, influence and response. The results show that the construction of national logistics hubs in Shanghai, Nanjing, Suzhou, Ningbo-Zhoushan, Jinhua and other cities in the Yangtze River Delta is obviously better than that in the central part of China. In order to adapt to the integrated development of Yangtze River Delta and enhance the status of Anhui province in the national logistics hub network, logistics hub cities in Anhui Province should take effective measures from five aspects of the model. For example, concentrate on developing the economy; optimize the urban transportation system; build distinctive industrial clusters; develop multimodal transport facilities; innovate smart logistics models; treasure the construction of cold chain logistics; strengthen macro policy support; building a response mechanism for ecological green development.