Applying hormesis in aging research and therapy

Rattan, S. I. S.

doi:10.1191/096032701701548034

Cited by 74 publications

(50 citation statements)

References 50 publications

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“…Hormesis and caloric restriction mild, repeated stress (Rattan, 2001). He further proposes that as an aging retardant, hormesis is based on the principle that repeated exposure to mild stress stimulates maintenance and repair processes (Rattan, 2004).…”

Section: Hormesis In Aging Refers To Beneficial Effects Resulting Fromentioning

confidence: 99%

Role of Hormesis in Life Extension by Caloric Restriction

Masoro¹

2007

Dose-Response

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ᮀ Caloric restriction (CR) markedly extends the life of rats, mice and several other species, and it also modulates age-associated physiological deterioration and delays the occurrence and/or slows progression of age-associated diseases. The level of CR that retards the aging processes is a low-intensity stressor, which enhances the ability of rats and mice of all ages to cope with intense stressors. CR thus exhibits a hormetic action in these species, and therefore it is hypothesized that hormesis plays a role in the life-extending and anti-aging actions of CR. Both the findings in support of this hypothesis and those opposing it are critically considered. However, it is likely that hormesis is not the only process contributing to CR-induced life extension. It is proposed that two general processes are involved in CR-induced life extension. One is the reduced endogenous generation of damaging agents, such as reactive oxygen species. The second is hormesis, which enhances processes that protect against the action of damaging agents and also promotes processes that repair the damage once it occurs.

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Section: Hormesis In Aging Refers To Beneficial Effects Resulting Fromentioning

confidence: 99%

Role of Hormesis in Life Extension by Caloric Restriction

Masoro¹

2007

Dose-Response

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“…Although most of the work on hormesis has been driven by pharmacological and toxicological studies, applying hormesis in aging research and therapy is a recent development (Johnson and Bruunsgaard, 1998;Kiang and Tsokos, 1998;Rattan, 1998Rattan, , 2001.…”

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms of Anti-Aging Hormetic Effects of Mild Heat Stress on Human Cells

Rattan

Eskildsen‐Helmond

Beedholm

2004

Nonlinearity in Biology, Toxicology, Medicine

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“…They looked at a broad group of taxa, from bacteria to mammals, exposed to inorganics (Nascarella et al, 2003), organics (Laughlin et al, 1981;Zanuncio et al, 2003), heat (Hercus et al, 2003), and gamma radiation (Pollycove and Feinendegen, 2001). In order of frequency observed, hormetic effects were increase in growth, longevity (Cypser and Johnson, 2002;Rattan, 2001), reproduction, survival, and also metabolic effects.…”

Section: Introductionmentioning

confidence: 92%

Hormetic Effects of Heavy Metals in Aquatic Snails: Is a Little Bit of Pollution Good?

et al. 2008

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Hormesis is the term to describe a stimulatory effects associated with a low dose of a potentially toxic substance or stress. We had anecdotal evidence of hormetic effects in some of our previous experiments concerning the influence of heavy metals on aquatic snail growth and recruitment. We therefore repeated a version of an earlier experiment but this time we expanded our low-dose treatments and increased our sample size. We also explored if metals had a hormetic effect on algae periphyton. We raised snails in outdoor mini-ecosystems containing lead, zinc, and cadmium-contaminated soil from an Environmental Protection Agency Superfund site in the Silver Valley of northern Idaho. The snails came from two sites. One population (Physella columbiana) has evolved for 120 years in the presence of heavy metals and one (Lymnaea palustris) has not. We found that P. columbiana exhibited hormesis with snails exposed to small amounts of metals exhibiting more reproduction and growth than snails not exposed to metals. Naturally occurring Oscillatoria algae also exhibited a hormetic effect of heavy metals but L. palustris did not display hormesis. Large doses negatively impacted all three species. Overall the levels of cadmium, lead, and zinc measured in the tissues of the snails were inversely correlated to the number of snails recruited into the tub populations. Only in comparisons of the lowest metal treatment to the control treatment is a positive effect detected. Indirect effects on competing species of snails, periphyton, and also fishermen, may be less favorable.

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Applying hormesis in aging research and therapy

Cited by 74 publications

References 50 publications

Role of Hormesis in Life Extension by Caloric Restriction

Role of Hormesis in Life Extension by Caloric Restriction

Molecular Mechanisms of Anti-Aging Hormetic Effects of Mild Heat Stress on Human Cells

Hormetic Effects of Heavy Metals in Aquatic Snails: Is a Little Bit of Pollution Good?

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