This scoping review of studies on patients' mental workload (MWL) in health education via e‐learning was conducted to characterize the state of research and to identify barriers to and facilitators of e‐learning. The Cochrane Library, PubMed, Embase, Web of Science, and PsycINFO electronic databases were searched through September 10, 2023. A descriptive analysis of study characteristics and a content analysis of barriers to and facilitators of MWL were conducted. Among the 2837 studies screened for eligibility, 38 were included. A relatively small number of articles used a comprehensive framework to explore barriers to and facilitators of e‐learning or used indicators of MWL to assess application usability and user experience. Analyses of factors influencing the effectiveness of e‐learning in health education identified key predictors across five domains: individual, task, technical, environmental, and interactive aspects. The incorporation of multifaceted influencing factors that contribute to optimizing the MWL should be a priority when using e‐learning in health education. Future research should give more attention to investigating the generative mechanism of e‐learning in health education to enhance targeted program design.