ALJBIRI ATIYA: Factors aff ecting Gumhoria Bank's profi tability. Empirical evidence from biggest commercial bank in Libya. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013, LXI, No. 7, pp. 1941-1949 The main purpose of this paper is to examine the factors aff ecting the profi tability of (Gumhouria) bank in Libya, over the time period from 2000 to 2010. Return on equity (ROE) is used as profi tability measures to determine the aff ect of internal and external factors on profi tability. The descriptive, correlation and regression analysis results are derived with the help of SPSS. The results show that all factors (Portfolio Composition, Capital Adequacy, Deposits, Size, GDP, CPI), establish positive relation with profi tability as measured by (ROE) in diff erent signifi cance.