Applying prevention concepts to anaphylaxis: A call for worldwide availability of adrenaline auto‐injectors

Tanno, Luciana Kase; Simons, F. Estelle R.; Sánchez‐Borges, Mario; Cardona, Victòria; Moon, Hee‐Bom; Calderón, Moisés A.; Sisul, Juan Carlos; Muraro, Antonella; Casale, Thomas B.; Demoly, Pascal

doi:10.1111/cea.12973

Cited by 40 publications

(42 citation statements)

References 31 publications

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“…In the present study, we demonstrated that anaphylaxis was responsible for 0.16% of ED admissions, with an incidence estimated at 34 per 100 000 person-years. Although injectable epinephrine is currently listed in the WHO list of essential drugs for the treatment of anaphylaxis, our findings were remarkable in that it was rarely prescribed, even in severe cases [18]. This finding is consistent with most recently published data in the field [2][3][4][5][6][7][8][9][10].…”

Section: Discussionsupporting

confidence: 91%

“…For this reason, we included additional codes related to manifestations and causes that could resemble or induce anaphylaxis or even allergic reactions (Table 1). Over the last 5 years, a strategic international action plan supported by the Joint Allergy Academies and the WHO [11,17,18,[26][27][28][29][30][31] was implemented to update the classifications of allergic conditions for the new edition of the ICD. These efforts resulted in the construction of the new "Allergic and hypersensitivity conditions" section in ICD-11 [28,32], with a subsection dedicated exclusively to anaphylaxis.…”

Section: Discussionmentioning

confidence: 99%

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Epidemiological Data on Anaphylaxis in French Emergency Departments

Corriger¹,

Beaudouin²,

Rothmann³

et al. 2019

J Investig Allergol Clin Immunol

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Background: Although anaphylaxis has been considered a priority public health issue in the world allergy community, epidemiological data on morbidity and mortality remain suboptimal. We performed the first multicenter epidemiological study in French emergency departments (EDs). The study covered 7 EDs over a period of 1 year. The objectives were to identify areas that are amenable to change and to support ongoing national and international efforts for better diagnosis, management, and prevention of anaphylaxis. Methods: Ours was a descriptive study based on data routinely reported to French institutional administrative databases from 7 French public health institutions in the Lorraine region between January and December 2015. Data were collected based on the anaphylaxisrelated codes of the International Classification of Diseases (ICD)-10, and cases were clinically validated as anaphylaxis. Results: Of the 202 079 admissions to the EDs, 4817 had anaphylaxis-related codes; of these, 323 were clinically validated as anaphylaxis. Although 45.8% were severe, adrenaline was prescribed in only 32.4% of cases. Of the 323 cases, 57.9% were subsequently referred for an allergy work-up or evaluation (after or during hospitalization), and 17.3% were prescribed autoinjectable epinephrine. Conclusion: Our results highlight an urgent need for improved public health initiatives with respect to recognition and treatment of anaphylaxis. We flag key problems that should be managed in the coming years through implementation of national and international actions.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Epidemiological Data on Anaphylaxis in French Emergency Departments

Corriger¹,

Beaudouin²,

Rothmann³

et al. 2019

J Investig Allergol Clin Immunol

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“…Taking the opportunity presented by the ongoing ICD-11 revision, the under-notification of death data [ 12 ] triggered a cascade of strategic international actions supported by the Joint Allergy Academies and the ICD WHO governance [ 11 – 23 ] to update the classifications of allergic conditions for the new ICD edition. These efforts have resulted in the construction of the new “Allergic and hypersensitivity conditions” section built under the “Disorders of the Immune system” chapter [ 17 , 24 ].…”

Section: Anaphylaxis Epidemiology: Open Introductory Questionsmentioning

confidence: 99%

Critical view of anaphylaxis epidemiology: open questions and new perspectives

Tanno

Bierrenbach²,

Simons

et al. 2018

Allergy Asthma Clin Immunol

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In contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can differ widely depending on a number of variables. In the current document we reviewed the forms on which anaphylaxis has been defined and classified; and how it can affect epidemiological data. With regards to the methods used to capture morbidity statistics, we observed the impact of the anaphylaxis coding utilizing the World Health Organization’s International Classification of Diseases. As an outcome and depending on the anaphylaxis definition, we extracted the cumulative incidence, which may not reflect the real number of new cases. The new ICD-11 anaphylaxis subsection developments and critical view of morbidity statistics data are discussed in order to reach new perspectives on anaphylaxis epidemiology.

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“…With the aim of having a better representation of allergic and hypersensitivity conditions, including anaphylaxis, in international classification systems and taking the window of opportunity presented by the ICD-11 revision, the documented anaphylaxis deaths under-notification data [7] triggered a cascade of strategic international actions acknowledged by a Joint Allergy Academies' consortium composed by six international regional allergy academies, the ICD WHO governance [6,7,[12][13][14][15][16][17][18][19][20] in order to update the classifications of allergic and hypersensitivity conditions for the new ICD edition. The design of the anaphylaxis subsection was based on the Allergic and hypersensitivity diseases proposal, which had been validated by crowd-sourcing [13] and simplified [15] according to ICD Revision Steering Group (RSG) guidance.…”

mentioning

confidence: 99%