Applying the Indirect Immunofluorescent Antibody Test (IFAT) for Detection of Coxiella Burnetii in Chronic Hepatitis Patients and Fever of Unknown Origin Patients from the Village with Direct Contact with Animals in Assiut Governorate

Abstract

Background: Q fever is a neglected zoonotic disease caused by the bacterium Coxiella burnetii. Although hepatitis is a one of the most presentations of Q fever, the attainable influence of chronic hepatitis C virus& hepatitis B virus, the apparent healthy person, and fever of unknown origin (FUO) in Q fever has, to our data, never been investigated. Clinical manifestation of Q fever in humans include cute, chronic to fatigue syndrome. It is a vital issue in regions where Q fever hepatitis and viral hepatitis are prevalent. Aim and Methods: We tend to conduct a study to research the possible attainable of viral hepatitis in cases of Q fever hepatitis. The serum samples were examined for IgM and IgG antibodies against C. burnetii antigen by indirect immunofluorescent antibody test (IFAT).The results showed that 20 patients with hepatitis C virus were studied, of whom 10(50%) IgM and 12 (60%) IgG had Q fever, A total of 40 patients with fever of unknown origin (FUO) studied (Patient suffer from fever, cough, rhinitis, nausea, vomiting (during winter), of whom 17 (42%) IgM and 18(45%) IgG had Q fever. Three samples from patients infected with Hepatitis B virus with kidney dialysis of whom 1(33%) IgM and IgG positive.10 samples from Apparent healthy persons of whom 3(30%) IgM positive 4(40%) IgG positive (females) one of them suffers from the reproductive disorder and another one suffer from toxic goitre. We concluded that we have a tend to terminate that the data on the medicine of Q fever in Egypt is proscribed with no attention to regulate and hindrance programs. The results of this study boost the data on the on the prevalence of fever of unknown origin (FUO). Corroding to our knowledge, Q fever influences the replication of hepatitis virus is continues to be not understood and wishes more studies.