Purpose: Primary care practices are an ideal setting for reducing national smoking rates because >70% of smokers visit their physician annually, yet smoking cessation counseling is inconsistently delivered to patients. We designed and created a novel software program for handheld computers and hypothesized that it would improve clinicians' ability to provide patient-tailored smoking cessation counseling at the point of care.Methods: A handheld computer software program was created based on smoking cessation guidelines and an adaptation of widely accepted behavioral change theories. The tool was evaluated using a validated before/after survey to measure physician smoking cessation counseling behaviors, knowledge, and comfort/self-efficacy.Results: Participants included 17 physicians (mean age, 41 years; 71% male; 5 resident physicians) from a practice-based research network. After 4 months of use in direct patient care, physicians were more likely to advise patients to stop smoking (P ؍ .049) and reported an increase in use of the "5 As" (P ؍ .03). Improved self-efficacy in counseling patients regarding smoking cessation (P ؍ .006) was seen, as was increased comfort in providing follow-up to patients (P ؍ .04).Conclusions: Use of a handheld computer software tool improved smoking cessation counseling among physicians and shows promise for translating evidence about smoking cessation counseling into practice and educational settings. One third of the world's adult population smoke cigarettes (Ͼ1.1 billion people), resulting in nearly 5 million deaths annually, with projections of 10 million annual deaths if current global smoking patterns continue.1 Previous declines in smoking rates have stalled over the past 5 years, 2 and nearly half of the United States' 45.3 million current smokers are expected to die prematurely as a result of smoking.A recent Institute of Medicine report calls for implementing successful cessation methods and approaching smoking as a disease management issue, 3 yet it has been difficult to translate these recommendations into clinical practice. Excellent evidencebased guidelines for smoking cessation counseling have been available for more than 2 decades, and an update was published in 2008. Clinicians in primary care have the potential to impact national smoking rates; Ͼ70% of smokers visit their physician annually.8 Despite having these guidelines for smoking cessation available, physicians continue to perform poorly in delivering smoking cessation counseling to their patients. Goldstein et al. 9 found that a majority of community-based primary care physicians reported asking (67%) and advising (74%) their patients about smoking, but rates of assisting (35%) or arranging (8%) follow-up were much lower. Several additional studies have confirmed these low rates of recommended physician smoking cessation counseling, 10 -16 demonstrating the need for innovative, dynamic, and accessible methods to translate and disseminate smoking cessation counseling information to clinicians.Pe...