Apport de la tomographie par émission de positons couplée au scanner dans le diagnostic de leishmaniose viscérale

Casadevall, M.; Mambré, L.; Cornet, Muriel; Caillat-Vigneron, Nadine; Jeunne, Claire Le; Aslangul, E.

doi:10.1016/j.medmal.2010.06.003

Cited by 3 publications

(5 citation statements)

References 6 publications

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“…The predominant pattern was a "diffuse" pattern, detected in 55.3% (26 cases), 5,7,18-23 followed by "focal/nodular" pattern in 25.5% (12 cases). 7,24,25,27,28 There was no uptake in the spleen in seven cases. 7,[29][30][31] There was a "diffuse" uptake in 51.3% of immunocompetent patients and 40% of IS patients, and a "focal/nodular" pattern was found in 24.3% of immunocompetent patients and 13.3% of IS patients.…”

Section: Resultsmentioning

confidence: 89%

“…The remaining nine cases were simply described as an increased metabolism in the spleen [9][10][11][12][13][14][15][16] or an uptake compatible with lymphoma. 17 In the other cases, the FDG uptake in the spleen was described as "homogeneous" in one case, 18 "diffuse" in 19 cases, 7,[19][20][21][22][23] "diffuse and multifocal" in 10 cases, 5,7,22,24 "nodular" in two cases, 25,26 "patchy and granular" in one case, 27 and "with subcortical uptake" in one case. 28 The pattern of the uptake was variable, and information was not always available in the cases reported in literature.…”

Section: Resultsmentioning

confidence: 97%

“…being positive in the remaining two. 24,25 Biopsy was positive for Leishmania spp. in three non-IS patients.…”

Section: Resultsmentioning

confidence: 99%

“…The species of Leishmania was specified in 10 patients, showing L. infantum in six cases [12][13][14]23,25,30 and Leishmania donovani in the remaining four patients. 10,18,26,31 Splenectomy was performed in seven patients because of initial suspicion of malignancy.…”

Section: Resultsmentioning

confidence: 99%

“…Enhanced bone marrow metabolism was seen in 29 cases (six IS cases, 21 non-IS, and two immune status unknown). 7,9,14,15,[18][19][20][21][22][23][24][25][26][27]29 Of these, four resulted in a negative biopsy for Leishmania spp., 19,22,23,29 one was not biopsied, 26 and 11 cases were positive, 9,14,15,18,20,21,24,25,27 with six cases being IS, four cases non-IS, and one unknown. In the remaining 13 cases, biopsy was not specified.…”

Section: Resultsmentioning

confidence: 99%

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Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Visceral Leishmaniasis: Case Report and Literature Review

Pinnegar

Sánchez-Montalvà

Profitós

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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The diagnosis of visceral leishmaniasis (VL) is complicated and often unsuspected. Little is known of the usefulness of nuclear imaging in VL. Our objective was to describe findings seen in fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in cases of VL. We retrospectively reviewed VL cases diagnosed at Vall d’Hebron University Hospital from May 2012 to May 2018 and selected those that had an FDG-PET/CT performed. Information on procedures and details of the FDG-PET/CT features and follow-up were collected. We then systematically reviewed the literature on VL and FDG-PET/CT. Four of 43 patients diagnosed with VL had an FDG-PET/CT performed. All four patients presented diffuse splenic uptake of FDG-PET/CT. Adenopathy was not always present, and bone marrow uptake was found in two patients. A posttreatment FDG-PET/CT in one patient revealed normalization of initial findings. In the literature review, 43 of 50 cases presented similar splenic uptake in the PET/CT, being described as different patterns: “increased metabolism,” “homogeneous,” “diffuse,” “diffuse and multifocal,” “nodular,” “patchy and granular,” “subcortical,” and “compatible with lymphoma.” Other frequent findings were bone marrow uptake and adenopathies. We, therefore, conclude that FDG-PET/CT could become a useful tool for the diagnosis and follow-up of VL and that VL should be taken into account in patients with fever of unknown origin with enhanced splenic uptake in FDG-PET/CT. Differential diagnosis in these cases should be made with splenic primary lymphoma, virus infections, chemotherapy, and colony-stimulating factor therapy. Further structured studies with more cases are needed to define its diagnostic and prognostic value.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 97%

“…being positive in the remaining two. 24,25 Biopsy was positive for Leishmania spp. in three non-IS patients.…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Visceral Leishmaniasis: Case Report and Literature Review

Pinnegar

Sánchez-Montalvà

Profitós

et al. 2021

The American Journal of Tropical Medicine and Hygiene

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18F-FDG PET/CT in visceral leishmaniasis: uptake patterns in the context of a multiannual outbreak in Northern Italy

et al. 2019

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Focal Splenic FDG Uptake in a Patient With Kala-Azar (Visceral Leishmaniasis)

Fuertes

Garcia-Bennett²,

Iftimie³

et al. 2014

Clinical Nuclear Medicine

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We present a woman with a history of Gaucher disease and secondary portal hypertension. She went to hospital for treatment of resistant fever without apparent cause. A conventional study of fever of unknown origin did not show any pathology. For this reason, she was referred to our department for a PET/CT, which did not demonstrate a cause for the fever. Two months after, she was admitted again in hospital for fever recurrence. A new PET/CT showed FDG avid hypodense splenic lesions, suspicious for infection. Splenectomy was performed and histopathologic analysis demonstrated intracellular organisms compatible with Leishmania.

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Apport de la tomographie par émission de positons couplée au scanner dans le diagnostic de leishmaniose viscérale

Cited by 3 publications

References 6 publications

Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Visceral Leishmaniasis: Case Report and Literature Review

Utility of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Patients with Visceral Leishmaniasis: Case Report and Literature Review

18F-FDG PET/CT in visceral leishmaniasis: uptake patterns in the context of a multiannual outbreak in Northern Italy

Focal Splenic FDG Uptake in a Patient With Kala-Azar (Visceral Leishmaniasis)

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