Apport du logiciel Nadis® dans la collecte des effets indésirables des antirétroviraux : expérience en Midi-Pyrénées

Pochard, Liselotte; Hauviller, Laurent; Eyvrard, Frédéric; Sommet, Agnès; Montastruc, Jean‐Louis; Bagheri, Haleh

doi:10.2515/therapie/2013076

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…Out of the 90 studies, 16 were from France; eight from Italy; seven from the United States and Spain; six from the United Kingdom and Portugal; four from Iran and India; three from China, Sweden, and Mexico; two from Brazil, Denmark, Israel, Korea, the Netherlands, Switzerland, and the United Arab Emirates; and one each from Chile, Germany, Morocco, Nigeria, Saudi Arabia, South Africa, and Thailand. The interventions were designed as before‐after in 50 of the studies, non‐comparative in 17 studies, randomized controlled trial (RCT) and cluster RCT in nine studies, and other in 14 studies. In addition, most of the studies had been developed on HCPs, particularly physicians.…”

Section: Resultsmentioning

confidence: 99%

“…A computerized documentation system was implemented to standardize and facilitate reporting through easy use, customized data retrieval, and analysis in a number of studies . Various computerized registration methods were used alone (n = 8) or in combination with other interventions (n = 14) in these studies and had a nearly significant effect on reporting (an increase of 0.8 to 72.0‐fold).…”

Section: Resultsmentioning

confidence: 99%

“…Various computerized registration methods were used alone (n = 8) or in combination with other interventions (n = 14) in these studies and had a nearly significant effect on reporting (an increase of 0.8 to 72.0‐fold). These studies had been conducted in France, the United States, Spain, China, Portugal, Korea, Mexico, Italy, Taiwan, and the UAE…”

Section: Resultsmentioning

confidence: 99%

“…Some studies deployed online registration, such as an online ADR reporting system, a network‐based electronic notification system, online reporting through the website, and a free smartphone app for receiving the SR of pharmacovigilance. A tool for ADR reporting integrated into the hospital information system was another way for computerizing registration and facilitating reporting . In the study by Lombart et al, a new “drug‐related iatrogenesis” button was added to the emergency department software that enabled the emergency doctors to report an ADR when closing a patient's case file .…”

Section: Resultsmentioning

confidence: 99%

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Interventions to improve adverse drug reaction reporting: A scoping review

Khalili

Mesgarpour²,

Sharifi

et al. 2020

Pharmacoepidemiology and Drug

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Purpose Underreporting is the major limitation of a voluntary adverse drug reaction (ADR) reporting system. Many studies have assessed the effectiveness of different interventions designed to improve ADR reporting. The aim of this study was to systematically map interventions and strategies to improve ADR reporting among health care professionals. Methods The six‐stage methodological framework of Arksey and O'Malley was used to conduct this scoping review. Ovid MEDLINE, EMBASE, All EBM, and Web of Science were systematically searched from 1999 to February 2019, and the reference lists of the included papers were also searched for gray literature to identify any interventions and strategies that aimed to increase ADR reporting. Two reviewers screened the papers for eligibility based on the inclusion criteria and extracted their key data and analyzed them descriptively. Results Ninety out of 14 501 papers met the selection criteria. Using computerized registration and active surveillance can increase ADR reporting significantly. Educational interventions performed individually or combined with sending reminders and/or feedback, awards, and providing easier reporting channels can improve ADR reporting over a short to medium term. Multiple interventions may have more impact than single‐component interventions. Conclusion Multiple interventions could cause a greater increase in ADR reporting rates than single interventions. Although educational interventions appear to be effective, few studies have reviewed their long‐term effects to ascertain whether the improvements are sustained over time. Studies with a better methodological quality are required on this subject.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Interventions to improve adverse drug reaction reporting: A scoping review

Khalili

Mesgarpour²,

Sharifi

et al. 2020

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

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Virological and immunological impact of integrase inhibitor-based regimens initiated during primary HIV-1 infection

Poizot‐Martin

Reynes

Goujard

et al. 2020

Aids

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Design: Current international guidelines recommend either boosted protease inhibitor (PI/r)-based or integrase inhibitors (INSTI)-based regimens during primary HIV infection (PHI), even though the latter have only demonstrated their superiority at the chronic stage. We compared the effectiveness of INSTI-based versus PI/r-based combined antiretroviral therapy (cART) initiated during PHI. Methods: This study was conducted among patients who initiated cART between 2013 and 2017, using data from the ANRS-PRIMO cohort and the Dat’AIDS study. Cumulative proportions of patients reaching viral suppression (HIV-1 RNA <50 copies/ml) were calculated using Turnbull's estimator for interval-censored data. CD4+ cells and CD4+/CD8+ ratio increases were estimated using mixed linear models. Results were adjusted for the data source. Results: Among the 712 study patients, 299 received an INSTI-based cART. Patients’ baseline characteristics were similar between groups. Viral suppression was reached more rapidly in INSTI-treated versus PI/r-treated patients (P < 0.01), with cumulative proportions of 32 versus 6% at 4 weeks, 72 versus 31% at 12 weeks, 91 versus 78% at 24 weeks and about 95% in both groups at 48 weeks. At 4 weeks, INSTI-treated patients had gained on average 40 CD4+ cells/μl (P = 0.05) over PI/r-treated ones; mean CD4+ counts were similar in the two groups at 48 weeks. The CD4+/CD8+ ratio followed the same pattern. Results were similar when restricted to a comparison between dolutegravir-based versus darunavir-based cART. Conclusion: On the basis of this study and available literature, we recommend the use of INSTI-based cART for treatment initiation during PHI, as it leads to faster viral suppression and immune restoration.

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Apport du logiciel Nadis® dans la collecte des effets indésirables des antirétroviraux : expérience en Midi-Pyrénées

Cited by 2 publications

References 17 publications

Interventions to improve adverse drug reaction reporting: A scoping review

Interventions to improve adverse drug reaction reporting: A scoping review

Virological and immunological impact of integrase inhibitor-based regimens initiated during primary HIV-1 infection

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