Apport du screening toxicologique par CLHP/BD lors d'intoxications médicamenteuses

Dehan, Céline; Ponchel, C.; Bohand, Sandra; Moalic, Jean-Luc; Chevrier, Michel; Carpentier, J.-P.; Pauli, A

doi:10.1016/s0338-9898(01)80392-9

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Synthesis Of the Internal Standard1

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2023

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“…The N-acetylparoxetine is prepared in our laboratory by a total acetylation of pure paroxetine J Fundam Appl Sci. 2022, 14 (2), 351-367 357 certain molecules [32]. Our library also covers some metabolites whose identification simplifies the interpretation of chromatograms and provides useful information in some poisoning cases.…”

Section: Synthesis Of the Internal Standardmentioning

confidence: 99%

Toxicological screening method by HPLC-DAD with local spectral library and "home-made" internal standard

Sobhi,

Mélaïne,

Abdaoui

et al. 2023

J. Fundam and Appl Sci.

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A liquid-liquid extraction technique and HPLC-DAD method using a C18 column, 5μm (150x4.6mm i.d.) were developed for a toxicological drug screening. A home-made “N-acetylparoxetine” is used as internal standard. A local UV spectra library of over 130 drugs and some of their metabolites was created. This library covers the main therapeutic classes involved in intoxication cases. The developed procedure is successfully applied to different biological samples (serum, urine, gastric fluid and post mortem whole blood) and allows rapid and simultaneous detection and identification of a large number of substances and their semi-quantification in serum.

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Section: Synthesis Of the Internal Standardmentioning

confidence: 99%