Apports récents concernant l'allergie A L'A.C.T.H.

Charpin, J; Aubert, John‐David; Boutin, C.; OHRESSER, P

doi:10.1016/s0370-4688(65)80134-x

Cited by 3 publications

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“…As a matter of fact there was always the danger of sensitising the patient towards the animal protein with all the unwanted consequences such as anaphylactic shock in all its forms. These effects were seen indeed in about five percent of people repeatedly undergoing this therapy (1,2). For those reasons an iatrogenically inactivated adrenal cortex was often preferred as presenting a less serious risk than that accompanying regular administration of non-human protein hormone.…”

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confidence: 94%

Comparative trial with highly purified natural ACTH, synthetic ACTH 1—24 peptide and synthetic ACTH 1—39 peptide

Brombacher¹,

Buytendijk²,

Maesen³

1969

Clinical Chemistry and Laboratory Medicine

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Brombacher, Buytendijk and Maesen: Comparative trial with natural ACTH and synthetic ACTH peptides 291 Z. klin. Chem. u. klin. Biochem. 7. Jg., S. 291-292, Mai 1969 Comparative trial with highly purified natural ACTH, synthetic ACTH 1-24 peptide and synthetic ACTH 1-39 peptide The intensity and duration of the adrenocortical stimulation^ produced by highly purified natural porcine ACTH (44 U/m/), synthetic ACTH 1-24 peptide (0.44 mg tetracosapeptide/m/) and synthetic ACTH 1-39 peptide (0.4 mg l-39 peptide/m/) with all preparations dissolved in a gelatin solution, \vere investigated in one trial with a total of 18 healthy volunteers. The activity of synthetic ACTH 1-39 peptide significantly exceeds that of the synthetic 1-24 peptide, but is of shorter duration than that of the natural peptide. During long term treatment of patients with corticosteroids many clinicians require a means of reactivating the adrenal cortex which is therapeutically more or less suppressed. This is notably the case in the treatment of bronchial asthma, rheumatic disease and simular affections. Up till some years ago some more or less highly purified corticotropin preparations of animal origin were frequently used for the stimulation of the adrenal cortex. As a matter of fact there was always the danger of sensitising the patient towards the animal protein with all the unwanted consequences such as anaphylactic shock in all its forms. These effects were seen indeed in about five percent of people repeatedly undergoing this therapy (1, 2). For those reasons an iatrogenically inactivated adrenal cortex was often preferred as presenting a less serious risk than that accompanying regular administration of non-human protein hormone. This deadlock was solved by the availability of a polypeptide with corticotropic activity synthesized by SCHWYZER and KAPPELER (3). This peptide of fully synthetic origin did not induce sensibilization which · was also demonstrated with skin tests on patients known to react allergically to animal corticotropin (4). The non appearance of reactions came up to expectations because the sequence of the 24 amino acids of the synthetic product is the same as that in part of the natural ACTH molecule for many animal species and man (5). A certain disappointment however was felt when it became evident that the duration of action of the synthetic peptide was much shorter than for the natural hormone. Nevertheless with adequate dosage the effect was the same for both preparations for some hours after intravenous or intramuscular administration as measured by the increase of plasma cortisol levels. As was expected a very satisfactory effect was seen on continuous intravenous infusion (6), but there are practical objections to this. Consequently a definite want is felt for a synthetic preparation comparable to natural corticotropin with respect to duration of action and adrenal cortex stimulatory effect, but without the allergic properties of the latter. Possibly the shorter duration of action of the synthetic 24 amino aci...

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confidence: 94%

Comparative trial with highly purified natural ACTH, synthetic ACTH 1—24 peptide and synthetic ACTH 1—39 peptide

Brombacher¹,

Buytendijk²,

Maesen³

1969

Clinical Chemistry and Laboratory Medicine

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“…On account of the above advantages corticotropin has been increasingly used in many disease states requiring long-term therapy with corticosteroids (9, 13,16). However, the repeated injections of corticotropin of animal origin, a straight chain of 39-amino acids, frequently results in antibody formation, and its wide clinical application has been limited on account of serious allergic reactions (3,4,10,14,17,20) and the occasional development of acquired resistance (19). The sensitization is probably related to contaminated proteins and/or to N-25-N-33 species specific amino acid sequence (6).…”

Section: Introductionmentioning

confidence: 99%

“…A compound identical with the first 24 amino acids of corticotropin bas been recently synthesized by Kappeler & Schwyzcr (12) possessing little immunologic although full steroidigenie activity (7, ir, 18). This synthetic polypeptide-j8^-^' corticotropin seems to be free of allergic reactions, even in patients allergic to ACTH of animal origin (3,5,14). The depot form of this tetracosapeptide (Depot-Synacthen*) is now being studied and in tbis paper tbe clinical efficacy in asthmatic patients of its intermittent long-term administration is described.…”

Section: Introductionmentioning

confidence: 99%