Apposition of mononuclear cells to langerhans cells in contact allergic reactions. An ultrastructural study

Silberberg, Inga

doi:10.2340/0001555553112

Cited by 197 publications

(3 citation statements)

References 5 publications

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“…The fine-structure analysis showed that Langerhans' cell-lymphocyte contacts are not specific for allergic reactions as was originally suggested by Silberberg (20). Our observa tion is in accordance with the recent report of Lindberg and Forslind (8), that occlusion, per se, results in apposition ofLangerhans' cells to mononuclear cells.…”

Section: Discussionsupporting

confidence: 92%

T and B lymphocytes, macrophages and Langerhans´ cells during the course of contact allergic and irritant skin reactions in man

Ranki,

Kanerva,

Förström

et al. 1983

Acta Derm Venereol

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The in situ distribution of lymphocyte subclasses, macrophages and Langerhans´ cells was analysed with histochemical (ANAE staining), immunohistochemical (immunoperoxidase) and electron microscopic methods during the course of epicutaneous allergic and irritant skin reactions. Serial biopsies were taken during the first 5-72 hours following the allergen (nickel and chromium) or irritant (non-anoic acid and dithranol) application. Empty and petrolatum-filled Finn chambers were used as controls. No significant differences in the number of mononuclear inflammatory cells or their subclasses were found in the early recognition and elicitation phases of the allergic or irritant-induced reactions. Nor was there any difference in the frequency of lymphocyte-Langerhans´ cell contacts, although exocytic cells were most frequent in dithranol reactions.

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Section: Discussionsupporting

confidence: 92%

T and B lymphocytes, macrophages and Langerhans´ cells during the course of contact allergic and irritant skin reactions in man

Ranki,

Kanerva,

Förström

et al. 1983

Acta Derm Venereol

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“…No mononuclear cell 10 Lan gerhans cell apposition was found in the epidermis at sites of contact irritant reactions. This corresponds 10 our findings in contact-irritant reactions in the epidermis of man ( 12). On rare occasions mononuclear cells were seen apposed to Langerhans cells in the dermis.…”

Section: F Co111act-irrita111 Reactions To Dncbsupporting

confidence: 91%

“…In our previous ultrastructural studies in man (12,13,14) we showed the features of early apposition of mononuclear cells to Langerhans cells• and sub sequenl damagc to some Langerhans cells• in con tact allergic reactions. No such changes were seen in contact irritant reactions.…”

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confidence: 67%