Appraisal of the LIFT and BIOLIFT procedure: initial experience and short-term outcomes of 33 consecutive patients

Chew, Min‐Hoe; Lee, Peter J. M.; Koh, Cherry; Chew, Hwee E.

doi:10.1007/s00384-013-1702-0

Cited by 17 publications

(6 citation statements)

References 22 publications

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“…174 The LIFT procedure appears to be a safe and effective sphincter-sparing management option for complex fistulas, with a very acceptable rate of success, even in recurrent disease. Failure is higher in anterior 175 and longer 168 fistulas, but repeat procedures remain feasible. Downstaged tracks may be amenable to fistulotomy.…”

Section: Lift Proceduresmentioning

confidence: 99%

Hemorrhoids and Fistulas: New Solutions to Old Problems

Rakinic¹,

Poola²

2014

Current Problems in Surgery

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Section: Lift Proceduresmentioning

confidence: 99%

Hemorrhoids and Fistulas: New Solutions to Old Problems

Rakinic¹,

Poola²

2014

Current Problems in Surgery

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“…Only two studies were randomised controlled trials. Likewise, healing rates for the BioLIFT procedure have ranged between 63% and 94% in individual studies, most of which are case series 13 15 16. To our knowledge, this study would be the first systematic review comparing healing rates of BioLIFT versus LIFT.…”

Section: Discussionmentioning

confidence: 99%

Comparison of BioLIFT versus LIFT for the treatment of trans-sphincteric anal fistula: a protocol for systematic review and meta-analysis

Ahn,

Hu,

Gilbert

et al. 2023

BMJ Open

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IntroductionIdentifying the optimal treatment for anal fistula has been challenging. Since first reported in 2007, the ligation of the intersphincteric fistula tract (LIFT) procedure has reported healing rates between 40% and 95% and is being increasingly adopted. The BioLIFT is an augmentation of the LIFT with an intersphincteric bioprosthetic mesh and has reported healing rates between 69% and 94%. Despite increased costs and potential complications associated with mesh, the evidence comparing healing rates between BioLIFT and LIFT is unknown. This study details the protocol for a systematic review and meta-analysis of BioLIFT and LIFT to compare outcomes associated with each procedure.Methods and analysisMEDLINE, EMBASE and the Cochrane Database will be searched from inception using a search strategy designed by an information specialist. Randomised controlled trials, prospective and retrospective cohort studies, consecutive series, cross-sectional studies and case series with more than five patients will be included. Both comparative and single group studies will be included. The eligible population will be adult patients undergoing BioLIFT or LIFT for trans-sphincteric anal fistula. The primary outcome will be primary healing rate. Secondary outcomes will capture secondary healing rate and complications. Abstract, full text and data extraction will be completed independently and in duplicate by two reviewers. Study risk of bias will be assessed using Risk of Bias In Non-randomized Studies - of Interventions and the Risk of Bias (RoB 2.0) tool. Quality of evidence for outcomes will be evaluated using Grading of Recommendations, Assessment, Development and Evaluations criteria. A meta-analysis will be performed using a random-effects inverse variance model. Subgroup and sensitivity analyses will be explored in relation to complex fistula characteristics and patients who have undergone previous LIFT. Heterogeneity will be assessed using the I2statistic.Ethics and disseminationThis review does not require research ethics board approval. This study will be completed in September 2022. The findings of this study will be disseminated through peer-reviewed international conferences and journals.PROSPERO registration numberCRD42020127996.

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“…Anteriorly located fistulae fared significantly worse in their series. 24 The same group from Australia recently published a follow-up study of 13 patients who in total had 16 fistulae. The authors concluded that with the addition of a simple lay-open fistulotomy for subsequent fistulae, the success rate was increased from 68.8% to 81.3%.…”

Section: Complicationsmentioning

confidence: 97%