Knowledge management itself is a complex activity related to building organizational capabilities to integrate various forms of interactive technology with critical social, cultural, and organizational issues of knowledge workers. This becomes the core of all aspects of KM—knowledge creation, sharing, transformation, and retention—in the organization. Development of an effective KM strategy via adopting the appreciative inquiry approach can decide on the future of the robustness of organizations, organizational transformation, and eventually enhances the scope of competitive advantage. This chapter will incorporate the tenets of KM and ancillary practices, theory of organizations, though the lens of appreciative inquiry approach and the way an organization's structural transformation can be influenced by strategic management of knowledge within the organization. It will concurrently demonstrate the index of strategic influence within the overall organizational network.