Approach for determination of ATP:ADP molar ratio in mixed solution by surface-enhanced Raman scattering

Fang, Hui; Yin, Hong Jun; Lv, Mingyang; Xu, Hai Jun; Yong, Zhao; Zhang, Xin; Wang, Zheng; Liu, Luo; Tian, Tan

doi:10.1016/j.bios.2015.02.023

Cited by 36 publications

(18 citation statements)

References 34 publications

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“…with new bands detected at ca. 1175, 1216 and 1253 cm-1 and no detection of the 1123 cm-1 band, similarly to what was observed in the literature in the spectrum of ATP bound to a Au/CW substrate in a neutral environment (pH�7) (62). These modifications indicate that the phosphate subunit of ATP is clearly involved also in the adsorption process.…”

Section: Physico-chemical Characterization Of the Solids Before And Asupporting

confidence: 87%

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

Hammami

Elfeki

Marsan

et al. 2016

Applied Surface Science

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Section: Physico-chemical Characterization Of the Solids Before And Asupporting

confidence: 87%

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

Hammami

Elfeki

Marsan

et al. 2016

Applied Surface Science

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“…Raman spectroscopy is a powerful and highly sensitive analytical technique yielding individual molecular spectra (fingerprints). It is now increasingly being applied in various fields from fundamental research to engineering in physics, biology, environmental science, and chemistry 1 2 3 4 5 6 . However, it has only acted as a supplement to techniques using the infrared spectrum because of its low efficiency, as only one of every 10 8 incident photons is scattered to produce a Raman signal.…”

mentioning

confidence: 99%

A rapid method to authenticate vegetable oils through surface-enhanced Raman scattering

Zhang

Ren

et al. 2016

Sci Rep

Self Cite

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Vegetable oils are essential in our daily diet. Among various vegetable oils, the major difference lies in the composition of fatty acids, including unsaturated fatty acids (USFA) and saturated fatty acids (SFA). USFA include oleic acid (OA), linoleic acid (LA), and α-linolenic acid (ALA), while SFA are mainly palmitic acid (PA). In this study, the most typical and abundant USFA present with PA in vegetable oils were quantified. More importantly, certain proportional relationships between the integrated intensities of peaks centered at 1656 cm−1 (S1656) in the surface-enhanced Raman scattering spectra of different USFA were confirmed. Therefore, the LA or ALA content could be converted into an equivalent virtual OA content enabling the characterization of the USFA content in vegetable oils using the equivalent total OA content. In combination with the S1656 of pure OA and using peanut, sesame, and soybean oils as examples, the ranges of S1656 corresponding to the National Standards of China were established to allow the rapid authentication of vegetable oils. Gas chromatograph-mass spectrometer analyses verified the accuracy of the method, with relative errors of less than 5%. Moreover, this method can be extended to other detection fields, such as diseases.

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“…Figure a–c showcases the SERS map of intracellular ATP distribution in both cancer cells and cancer stem cells from breast, pancreatic and lung cancer cells respectively. The SERS peak of distinctive of ATP molecules can be attributed to CN stretching, C5–N7 stretching, and adenine ring breathing . The ultrahigh sensitivity of the mobile quantum organic probe has proven to be a competent sensor since the relative levels ATP provide crucial information reflecting the living state of a cell.…”

Section: Resultsmentioning

confidence: 99%

Detecting the Origin of Cancer‐Mobile Quantum Probe for Single Cancer Stem Cell Detection

Ganesh

Venkatakrishnan

Tan

2019

Adv Funct Materials

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Cancer stem cells (CSC) are believed to be the driving force of cancer metastases and are a rare population of self‐renewing cells that contribute majorly to the poor outcomes of cancer therapy. The detection of CSC is of utmost importance to shed light on the indestructible nature of certain solid tumors and their metastatic ability. However, tumors tend to harbor CSCs in a specialized niche, making the detection process difficult. Currently, there is no method available to detect CSCs. The significance of this work is twofold. First, to the best of the knowledge, it is the first time that the detection of CSC is demonstrated. This approach simultaneously detects both the phenotypic and the metabolic state of the cell, thus enabling universal detection of CSC with high accuracy. Second, to the best of the knowledge, for the first time, light is shed on cell chemistry of CSC in their dedicated niche to facilitate a better understanding of the key players involved in the metabolic rewiring of CSC. This work will enable a better understanding of the fundamentals of CSCs, which are critical for the early diagnosis of cancer and the development of therapies for the cure of cancer.

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Approach for determination of ATP:ADP molar ratio in mixed solution by surface-enhanced Raman scattering

Cited by 36 publications

References 34 publications

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

Adsorption of nucleotides on biomimetic apatite: The case of adenosine 5⿲ triphosphate (ATP)

A rapid method to authenticate vegetable oils through surface-enhanced Raman scattering

Detecting the Origin of Cancer‐Mobile Quantum Probe for Single Cancer Stem Cell Detection

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