Approach Phytochemistry of Secondary Metabolites of Maytenus Guianensis Klotzsch Ex Reissek (Celastraceae)

Lima, Renato Abreu; Hurtado, Fernanda Bay; Meneguetti, Dionatas Ulisses de Oliveira; Facundo, João Bezerra; Militão, Júlio Sancho Linhares Teixeira; Facundo, Valdir Alves

doi:10.5902/2179460x22021

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…Coumarins are rare in Celastraceae species since only four of them have been reported from Gymnosporia senegalensis var. spinosa [39], Euonymus hamiltonianus [40], the Brazilian species, Maytenus guianesis [20], and recently, in Monteverdia communis [41]. The results in the present work are in accordance with those previous reported, since coumarins were only detected in the fruits of Q. ilicina and root bark of E. enantiophyllus.…”

Section: Phytochemical Analysissupporting

confidence: 92%

“…Saponins were detected in all the species under study, which is in agreement with previous phytochemical studies in Celastraceae species [20][21][22]. Flavonoids were detected in all the analyzed organs, in agreement with studies on two Brazilian species, Maytenus aquifolium and Maytenus ilicifolia [23], used as anti-ulcer phytopharmaceuticals.…”

Section: Phytochemical Analysissupporting

confidence: 90%

“…All root bark extracts analyzed presented QMTs, a relatively limited group of biologically active compounds restricted to the Celastraceae species and are regarded as chemotaxonomic markers for this plant family [43]. QTMs have been reported exclusively in the root bark of species from Maytenus [18,20], Euonymus [44], and Celastrus genera [45].…”

Section: Phytochemical Analysismentioning

confidence: 99%

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Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Núñez,

Martínez,

Castillo

et al. 2024

Plants

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Chagas disease and leishmaniasis are among the most widespread neglected tropical diseases, and their current therapies have limited efficacy and several toxic side effects. The present study reports the chemical and antikinetoplastid profiles of extracts from five Salvadoran Celastraceae species against theTrypanosoma cruzi epimastigotes stage and Leishmania amazonensis and Leishmania donovani promastigote forms. The phytochemical profile evinced the presence of flavonoids, tannins, sterols, and triterpenes as the main components in all plant species, whereas quinonemethide triterpenoids (QMTs) were restricted to the root bark of the studied species. Antikinetoplastid evaluation highlights the root bark extracts from Zinowewia integerrima, Maytenus segoviarum, and Quetzalia ilicina as the most promising ones, exhibiting higher potency against T. cruzi (IC50 0.71–1.58 µg/mL) and L. amazonensis (IC50 0.38–2.05 µg/mL) than the reference drugs, benznidazole (IC50 1.81 µg/mL) and miltefosine (IC50 2.64 µg/mL), respectively. This potent activity was connected with an excellent selectivity index on the murine macrophage J774A.1 cell line. These findings reinforce the potential of QMTs as antikinetoplastid agents for the development of innovative phytopharmaceuticals and the plant species under study as a source of these promising lead compounds.

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Section: Phytochemical Analysissupporting

confidence: 92%

Section: Phytochemical Analysissupporting

confidence: 90%

Section: Phytochemical Analysismentioning

confidence: 99%

See 1 more Smart Citation

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Núñez,

Martínez,

Castillo

et al. 2024

Plants

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“…The assays for the in vitro identification of chemical constituents present in the aqueous and hydroalcoholic extracts were performed following the methodology described in the literature [18]. The results were evaluated visually and classified as positive or negative.…”

Section: Analysis Of Secondary Metabolitesmentioning

confidence: 99%

Effect of the solid state fermentation of cocoa shell on the secondary metabolites, antioxidant activity, and fatty acids

Lessa

Reis

Leite

et al. 2017

Food Sci Biotechnol

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During cocoa ( L.) processing, the accumulated cocoa shell can be used for bioconversion to obtain valuable compounds. Here, we evaluate the effect of solid-state fermentation of cacao flour with on secondary metabolite composition, phenol, carotenoid, anthocyanin, flavonol, and fatty acids contents, and antioxidant activity. We found that the total concentrations of anthocyanins and flavonols did not change significantly after fermentation and the phenolic compound and total carotenoid concentrations were higher. The fermentation process produced an increase in saponin concentration and antioxidant activity, as well as significant changes in the levels of oleic, linoleic, gamma-linolenic, and saturated fatty acids. Based on our findings, we propose that the reuse of food residues through solid state fermentation is viable and useful.

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Approach Phytochemistry of Secondary Metabolites of Maytenus Guianensis Klotzsch Ex Reissek (Celastraceae)

Abstract: The Brazilian Amazon rainforest, even for its richness and biological diversity, can offer the opportunity for innovative and efficient discovery of molecules with potential use in large scale. The interest in secondary metabolites

Cited by 2 publications

References 8 publications

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Salvadoran Celastraceae Species as a Source of Antikinetoplastid Quinonemethide Triterpenoids

Effect of the solid state fermentation of cocoa shell on the secondary metabolites, antioxidant activity, and fatty acids

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