Approach to differentiate between hyaluronic acid skin quality boosters and fillers based on their physicochemical properties

Abstract

Background The clinical indications, applications, and effect of the injectable hyaluronic acid range skin quality boosters (SQBs) are different than those of filler products. Material properties are increasingly being discussed for differentiation and in connection with clinical effects and esthetic indications. Aims The aim of this study is to evaluate whether SQB products can be differentiated from filler products by their physicochemical material properties. Material and methods Physicochemical properties (extrusion force, swelling degree, rheology, and cohesivity) of two SQBs (BELR, JUVVE) were compared with those of fillers (BELB, JUVVT) using the same manufacturing technology. Results Cohesivity was almost equal for SQBs and fillers. Few statistically significant differences in physicochemical properties were found. Properties of SQBs differed from fillers mainly in their delta of rheological properties and extrusion force. Conclusion In this study, physicochemical differences between SQB and filler were determined and described, supporting the presence of two categories and their different clinical indications and applications.

Rheological properties and preclinical data of novel hyaluronic acid filler containing epidermal growth factor

“…24 The biophysical properties of the HA-EGF filler indicate that the filler is not a suitable biomaterial for use as a space-filling gel in the dermis, where it is subjected to very low shear forces. According to Kleine et al, 25 skin quality boosters demonstrated lower viscosity and complex viscosity (η* and G′) than dermal fillers which are mainly used for volume augmentation. Since the HA-EGF filler showed similar rheology to the skin quality boosters that are available in the market, 25,26 we recommend that they be made available as skin boosters rather than dermal fillers.…”

“…According to Kleine et al, 25 skin quality boosters demonstrated lower viscosity and complex viscosity (η* and G′) than dermal fillers which are mainly used for volume augmentation. Since the HA-EGF filler showed similar rheology to the skin quality boosters that are available in the market, 25,26 we recommend that they be made available as skin boosters rather than dermal fillers. As the physicochemical properties depend on the EGF content of the HA-EGF filler, further investigation of the ideal composition is needed.…”

Stabilized composition of 26 mg/mL of high molecular weight HA for subcutaneous injection to improve skin quality

“…Skin quality is important to human attractiveness and significantly influences the perception of age, health, and youth across ethnicities [4] . Minimally invasive procedures have revolutionized the treatment paradigm for both facial and body skin rejuvenation and the recent history of cosmetic surgery [5] . In these procedures, the demand for treatments with hyaluronic acid (HA) injectables is constantly on the rise, and a large consensus has been gained worldwide for these products in aesthetic medicine and dermatology [4][5][6] .…”

“…Minimally invasive procedures have revolutionized the treatment paradigm for both facial and body skin rejuvenation and the recent history of cosmetic surgery [5] . In these procedures, the demand for treatments with hyaluronic acid (HA) injectables is constantly on the rise, and a large consensus has been gained worldwide for these products in aesthetic medicine and dermatology [4][5][6] . This market demand has driven the research and development of new advanced HA formulations for different clinical indications and applications while offering improved safety, effectiveness, and patient satisfaction.…”

Study of biological markers in skin quality treatment by subcutaneous injection of a stabilized composition of 26 mg/mL of high molecular weight HA

“…HA is a polysaccharide that plays a key role in the structural integrity and hydration of the skin [4] . Thus, HA is a molecule that is strongly involved in aging, and this fact drives the use of HA injectables as HA filler products to correct age-related facial contour abnormalities and rhytides due to its ability to function as a space-occupying device or as a skin booster product to notably improve skin quality by stimulation of the production of several extracellular matrix components [5][6][7] . With a large consensus on HA injectables globally, the demand for treatments with these products increases strongly and continuously in the world [1,[7][8][9][10] .…”