Approach to Mediastinal Fine Needle Aspiration Cytology

Xu, Huihong; Fan, Fang

doi:10.1097/pap.0000000000000355

Cited by 2 publications

(3 citation statements)

References 68 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Identifying the specific cysts that line the epithelium can aid in the diagnosis of certain cysts, such as bronchogenic cysts, which contain ciliated columnar epithelium or bronchial-type cells (Figure 2). Bronchogenic cysts may also contain seromucinous glands, fragments of islands of cartilage, or fascicles of smooth muscle, which can cause diagnostic confusion with normal tracheobronchial structures when sampled using EBUS-FNA [6,8]. Recognizing background cystic changes and correlating the changes to radiologic findings can be helpful in diagnosing cysts.…”

Section: Non-neoplastic Lesions 21 Cystic Lesionsmentioning

confidence: 99%

“…Thymic cysts can arise from a variety of processes in the anterior mediastinum, including congenital, inflammatory, or even neoplastic processes, that can present in unilocular or multilocular forms. Congenital thymic cysts arise from residual tissues of the third pharyngeal pouch that persist as a unilocular lesion, while acquired cysts from inflammatory processes tend to be multilocular [8,12,13]. FNA of thymic cysts demonstrates predominantly cyst contents and may be considered non-diagnostic unless epitheliumlining tissues and/or thymic tissues are also present.…”

Section: Cystic Lesionsmentioning

confidence: 99%

See 1 more Smart Citation

The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions

et al. 2023

View full text Add to dashboard Cite

Fine needle aspiration is a minimally invasive, low-morbidity, and cost-efficient technique for the sampling of mediastinal lesions. Additionally, ancillary testing on FNA samples can be used for the refinement of diagnoses and for treatment-related purposes (flow cytometry, cytogenetics, immunohistochemistry, and molecular diagnostics). Mediastinal lesions, however, can show a variety of lineages and morphologic features, giving rise to diagnostic dilemmas. As a result, the differential diagnosis can vary widely and becomes especially challenging due to the smaller sample size on FNA and the variability in component sampling. For appropriate patient management and to determine the correct treatment strategies, accurate pathologic diagnoses are paramount. In this review, we present the cytomorphologic features together with the immunophenotypic findings of mediastinal lesions, with emphasis on the diagnostic challenges and pitfalls in FNA cytology samples, including smears and cell block sections.

show abstract

Section: Non-neoplastic Lesions 21 Cystic Lesionsmentioning

confidence: 99%

Section: Cystic Lesionsmentioning

confidence: 99%

The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions

et al. 2023

View full text Add to dashboard Cite

show abstract

“…A clear pathological diagnosis of chest lesions is essential for the appropriate clinical management of these lesions. However, due to the complex anatomical location and close to the heart, lung aorta, and other important structures, the mediastinal and adjacent mediastinal lung tissue biopsy is a difficult challenge (1).…”

Section: Introductionmentioning

confidence: 99%

Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing thoracic lesions: a retrospective cohort study

Liao,

Zhu,

et al. 2024

Front. Med.

View full text Add to dashboard Cite

BackgroundEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive technique for biopsy of lung, peri-pulmonary tissue and lymph nodes under real-time ultrasound-guided biopsy. It is used in the diagnosis and/or staging of benign and malignant pulmonary and non-pulmonary diseases. Our study is based on a large sample size, in a diversified population which provides a representative real-world cohort for analysis.MethodsPatients who underwent EBUS-TBNA procedure between September 2019 and August 2022 were included in this retrospective study. For cases diagnosed as benign and unclassified lesions by EBUS-TBNA, the final diagnosis was determined by further invasive surgery or a combination of therapy and clinical follow-up for at least 6 months.ResultsA total of 618 patients were included in the study, including 182 females (29.4%) and 436 males (70.6%). The mean age of all patients was 61.9 ± 10.5 years. These patients were successfully punctured by EBUS-TBNA to obtain pathological results. The pathological diagnosis results of EBUS-TBNA were compared with the final clinical diagnosis results as follows: 133 cases (21.5%) of benign lesions and 485 cases (78.5%) of malignant lesions were finally diagnosed. Among them, the pathological diagnosis was obtained by EBUS-TBNA in 546 patients (88.3%) (464 malignant lesions and 82 benign conditions), while EBUS-TBNA was unable to define diagnosis in 72 patients (11.6%). 20/72 non-diagnostic EBUS-TBNA were true negative. The overall diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of EBUS-TBNA were 91.3%, 100%, 100%, 27.8%, and 91.6% [95% confidence interval (CI): 89.1–93.6%], respectively. In this study, only one case had active bleeding without serious complications during the EBUS-TBNA procedure.ConclusionGiven its low invasiveness, high diagnostic accuracy, and safety, EBUS-TBNA is worth promoting in thoracic lesions.

show abstract

Approach to Mediastinal Fine Needle Aspiration Cytology

Cited by 2 publications

References 68 publications

The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions

The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions

Endobronchial ultrasound-guided transbronchial needle aspiration for diagnosing thoracic lesions: a retrospective cohort study

Contact Info

Product

Resources

About