Approach to patients with hypertriglyceridemia

Chait, Alan; Feingold, Kenneth R.

doi:10.1016/j.beem.2022.101659

Cited by 5 publications

(2 citation statements)

References 96 publications

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“…The implementation of lifestyle interventions, such as dietary modifications, weight management, and increased physical activity, is considered the primary and most valuable approach for treating HTG. By significantly lowering TG levels through these interventions, it is possible to not only prevent pancreatitis but also reduce the risk of cardiovascular disease ( 2 , 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

The association between serum uric acid and hypertriglyceridemia: evidence from the national health and nutrition examination survey (2007–2018)

Tan

et al. 2023

Front. Endocrinol.

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BackgroundAccumulating evidence suggests that elevated serum uric acid (SUA) may be a risk factor for hypertriglyceridemia (HTG). However, the epidemiological evidence for the association between SUA and HTG is limited. This article aimed to use the data from National Health and Nutrition Examination Survey (NHANES) (2007–2018) database to bridge the research gap.MethodsThis cross-sectional study used data from 10027 adults involved in NHANES from 2007-2018. We designed the exposure variable as SUA and the outcome variable as HTG. The covariates included demographics, questionnaires, laboratory, and examination information. Weighted logistic regression and subgroup analysis were used to explore the independent association between SUA and HTG. Furthermore, interaction tests were also carried out to evaluate the strata differences. Generalized additive models (GAM), smooth curve fittings, and threshold effect analysis were applied to examine the non-linear relationship.ResultsA total of 10027 participants were included, of which 3864 were HTG participants and 6163 were non-HTG participants. After fully adjusting for confounders, weighted multiple logistic regression models revealed a 77% increase in the risk of HTG when each unit of log2-SUA increased. There was also a positive association between elevated log2-SUA and developed risk of HTG in the quartile (Q) groups (Q1 OR: 1.00; Q2 OR: 1.17 [95%CI: 0.95,1.45]; Q3 OR: 1.43 [95%CI: 1.16,1.78]; Q4 OR: 1.68 [95%CI: 1.36,2.08]. The subgroup analysis results remained consistent across strata, with a strong positive correlation between SUA and HTG. Interaction tests showed no dependence on physical activity (PA), gender, BMI, smoking status, alcohol intake, hypertension, and diabetes for this positive association between log2-SUA and HTG (all p for interaction >0.05). The participants’ age may impact the strength of the association between SUA and HTG (p for interaction <0.05).ConclusionThere is a positive association between SUA and HTG in US adults. Considering that SUA may be a risk factor for HTG, individuals diagnosed with HTG should prioritize the daily management of SUA as part of their comprehensive care.

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Section: Introductionmentioning

confidence: 99%

The association between serum uric acid and hypertriglyceridemia: evidence from the national health and nutrition examination survey (2007–2018)

Tan

et al. 2023

Front. Endocrinol.

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“…therapy, aimed at caloric and fat intake restriction, and pharmacological therapy are used to prevent the onset of acute pancreatitis [19][20][21], especially in severe HTG. However, the threshold of TG levels that increase the risk of developing acute pancreatitis, TG levels requiring aggressive therapeutic intervention, and target therapeutic levels remain unclear.…”

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confidence: 99%

Characterization of patients with acute idiopathic pancreatitis using an administrative claims database in Japan

Imura

Katada

2023

Preprint

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Background: Hypertriglyceridemia is one of the causes of idiopathic acute pancreatitis and atherosclerotic cardiovascular diseases. Most guidelines define fasting triglyceride levels greater than 150 mg/dL as hypertriglyceridemia; however the triglyceride level of patients with acute pancreatitis is not clear, nor is it known how much triglyceride level reduction can reduce cardiovascular events. This study aimed to characterize patients with acute idiopathic pancreatitis and especially focused on triglyceride levels, patient characteristics, pharmaceutical treatment, and prognosis. Methods: In this retrospective analysis of an administrative claims database, patients hospitalized due to acute pancreatitis were selected, and idiopathic pancreatitis was identified using specific pre-determined ICD-10 codes. A Wilcoxon rank sum test was performed for the comparison of the means of the two cohorts, and Fisher's exact test was used to compare proportions between the cohorts. The comparison between idiopathic and non-idiopathic pancreatitis was performed using a log-rank test. Results: Between April 1, 2008, and July 31, 2021, 44,005 patients were hospitalized for the treatment of pancreatitis; among them, 30,814 cases (70.0%) were categorized as idiopathic. The mean age of patients with idiopathic pancreatitis was 62.7±18.8 years, 68.8% of the patients were male, and the mean triglyceride levels within 3 days after hospitalization were 293.1±816.6 mg/dL. Rehospitalization due to recurrent pancreatitis and the incidence rates of cardiovascular events were 39.5% and 3.3%, respectively. Conclusions: Patients with idiopathic pancreatitis had elevated triglyceride levels at admission. Even if triglyceride levels are not extremely high, hypertriglyceridemia might cause idiopathic pancreatitis. Therefore, there is a need for intervention in terms of triglyceride levels in patients with hypertriglyceridemia, not only to prevent cardiovascular disease, but also to prevent the onset and recurrence of acute pancreatitis. Trial registration: Not applicable

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Bilibili, TikTok, and YouTube as Sources of Information on Acute Pancreatitis: Assessment and Analysis of Content and Quality (Preprint)

Ying,

Lai,

Wang

et al. 2024

Preprint

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BACKGROUND Background Acute pancreatitis is a primarily sterile inflammation caused by premature intracellular protease activation, which has caught the attention of social media platforms such as Bilibili, TikTok, and YouTube. However, the content and quality of medical information on social media exists unclear and indeterminate. OBJECTIVE The purpose of the study is to evaluate the content and quality of online videos about acute pancreatitis from Bilibili, TikTok, and YouTube METHODS Methods A video search using acute pancreatic-related keywords was conducted on three video-sharing platforms: Bilibili, TikTok, and YouTube. We recorded basic information presented in the videos and identified the source and content type of each video. The educational content and quality of each video were evaluated using the Global Quality Scale (GQS), Journal of the American Medical Association (JAMA), and Modified DISCERN. A comparative analysis was conducted on the videos obtained from these three sources. RESULTS Results 300 videos were considered for assessment. Most videos were provided by health professionals (50.7%, 152/300), followed by nonprofit organizations (27.7%, 83/300). Additionally, 13.2% of videos (36/300) were offered by science communicators, and 5.7% (17/300) were provided by general users. The remaining videos were uploaded by news agencies (3.3%, 10/300) and two for-profit organizations (0.7%, 2/300). The content types of the 300 videos were classified into five categories: clinical diagnosis (25%, 75/300), prognosis (5%, 15/300), etiologies and causations (6.7%, 20/300), scientific introductions (51%, 153/300), and treatment methods (12.3%, 37/300). The overall quality of the videos, as evaluated by GQS, JAMA, and Modified DISCERN, was found to be moderate, with scores of 2.67/5, 2.22/4, and 2.63/5 points, respectively. CONCLUSIONS Conclusions Video-sharing platforms have become easily accessible sources for patients seeking information about their diseases. This innovative study demonstrates that social media videos can facilitate public learning about clinical diagnosis, prognosis, treatment methods, etiologies and causations, and scientific introductions of acute pancreatitis. However, both the content and quality of uploaded videos are currently inadequate. In the future, greater efforts should be made to enhance the content and quality of videos on acute pancreatitis and increase public awareness.

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Approach to patients with hypertriglyceridemia

Cited by 5 publications

References 96 publications

The association between serum uric acid and hypertriglyceridemia: evidence from the national health and nutrition examination survey (2007–2018)

The association between serum uric acid and hypertriglyceridemia: evidence from the national health and nutrition examination survey (2007–2018)

Characterization of patients with acute idiopathic pancreatitis using an administrative claims database in Japan

Bilibili, TikTok, and YouTube as Sources of Information on Acute Pancreatitis: Assessment and Analysis of Content and Quality (Preprint)

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