“…In the continuous-flow synthesis of aldehydes from esters, the use of diisobutylaluminum hydride (DIBAL-H) has been widely reported [ 34 , 35 , 36 , 37 ], besides other related reducing agents, such as diisobutyl- tert -butoxyaluminum hydride (LDBBA) [ 38 ]. Reductive aminations also proved their utility in flow chemistry [ 39 ], especially when catalytic hydrogenation is used, which is well-suited to continuous transformations, since it is typically free from side-products, and the removal of excess hydrogen is fairly simple [ 40 , 41 ]. The application of reductive amination in continuous-flow hydrogenation equipment for API production has been reported in the literature [ 22 , 42 ].…”