Given a set of items, each with a profit and a weight and a conflict graph describing incompatibilities between items, the Disjunctively Constrained Knapsack Problem is to select the maximum profit set of compatible items while satisfying the knapsack capacity constraint. We develop a probabilistic tabu search heuristic with multiple neighborhood structures. The proposed algorithm is evaluated on a total of 50 benchmark instances from the literature up to 1000 items. Computational results disclose that the proposed tabu search method outperforms recent state-of-the-art approaches. In particular, our approach is able to reach 46 best known solutions and discover 8 new best known solutions out of 50 benchmark instances.