Recent exploration of the site of Kenchreai, the eastern port of Corinth in southern Greece, has focussed on a cemetery of subterranean chamber tombs dating chiefly to the Early Roman period (middle-late 1st to 3rd centuries AD). The copious but fragmentary human bones and teeth found in Tomb 10 have been disturbed since burial by natural processes, including bedrock erosion and the infiltration of moisture, roots and basic sediment, and by destructive looters. Nonetheless, the remains furnish considerable information about the mortuary practices of wealthy residents. Analysis of the remains in their archaeological and taphonomic contexts reveals that Tomb 10 contained at least 23 individuals, 15 inhumed in loculi and 8 cremated and placed in niches, sometimes in urns. The identification of males, females and subadults among the burned and unburned bones and teeth suggests that spouses, parents and children probably from several generations of the same lineage or household were buried here. The nature of the cremated fragments reflects a laborious process during which mourners burned bodies on substantial pyres at extremely high temperatures for a long time. Then they carefully extracted a representative sample of small fragments from throughout the reduced skeleton for burial at the tomb. This study contributes to a better understanding of mortuary practices in the Roman East, particularly the Greek world, where the chamber tomb was a common sepulchral type.