The once-only principle (OOP) aims to reduce interactions between citizens and governments, but many factors challenge its cross-border implementation. Building on the results of the “The Once-Only Principle Project” (TOOP, 2017–2021), an analysis was undertaken of the factors that either support or hinder implementation of the cross-border OOP. Five domains of factors were examined - technological, organizational, institutional aspects, actors and miscellaneous. This research highlights the importance of awareness of the OOP, and its inherent benefits, as a key driver. Also, the activities of supranational entities are of key significance, as it is establishing a critical legal framework. Co-ordination between different levels of government and different countries remains an important barrier. One specific issue discovered and addressed during the project but uncovered here, relates to identity matching, and this requires EU level intervention to reach an effective and efficient solution.