Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

Tamarov, Konstantin; Näkki, Simo; Xu, Wujun; Lehto, Vesa‐Pekka

doi:10.1039/c8tb00462e

Cited by 36 publications

(18 citation statements)

References 120 publications

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“…6 Advances in NP synthesis and increased use of these particles in many fields have led researchers to evaluate mechanisms to improve the biocompatibility of NPs. 7,8 In addition, increased use of NPs has resulted in interest in the development of green approaches for the fabrication of NPs. Biological synthesis has several advantages including reduced production of toxic by-products, improved stability, and reduced toxicity against healthy cells.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

122

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Background: The emergence of multi drug-resistant (MDR) bacterial infections and cancer has necessitated the development and discovery of alternative eco-safe antibacterial and anticancer agents. Biogenic fabrication of metallic nanoparticles is an emerging discipline for production of nanoproducts that exert potent anticancer and antibacterial activity, and do not suffer from the limitations inherent in physiochemical synthesis methods. Methodology: In this study, we isolated, purified, and characterized a novel cyanobacteria extract (Desertifilum IPPAS B-1220) to utilize in biofabrication of silver nanoparticles (D-SNPs). D-SNPs were produced by adding Desertifilum extract to silver nitrate solution under controlled conditions. Biofabrication of D-SNPs was confirmed using a UV-Vis spectrophotometer. The resultant D-SNPs were characterized using XRD, FTIR, SEM, and TEM. The toxicity of D-SNPs against five pathogenic bacteria and three cancer cell lines (MCF-7, HepG2, and Caco-2) was evaluated. Results: Formation of D-SNPs was indicated by a color change from pale yellow to dark brown. The peak of the surface plasmon resonance of the D-SNPs was at 421 nm. The XRD detected the crystallinity of D-SNPs. FTIR showed that polysaccharides and proteins may have contributed to the biofabrication of D-SNPs. Under SEM and TEM, the D-SNPs were spherical with diameter ranges from 4.5 to 26 nm. The D-SNPs significantly suppressed the growth of five pathogenic bacteria, and exerted cytotoxic effects against MCF-7, HepG2, and Caco-2 cancer cells with IC 50 values of 58, 32, and 90 µg/mL, respectively. Conclusion: These findings showed for the first time the potentiality of novel cyanobacteria strain Desertifilum IPPAS B-1220 to fabricate small SNPs that acted as potent anticancer and antibacterial material against different cancer cell lines and pathogenic bacterial strains. These findings encourage the researchers to focus on cyanobacteria in general and especially Desertifilum sp. IPPAS B-1220 for synthesizing different NPs that opening the window for new applications.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria Desertifilum sp. extract: Their Antibacterial and Cytotoxicity Effects

Hamida

Abdelmeguid

Ali

et al. 2020

IJN

122

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“…First, a long‐term and systematic study of the safety of PSiNPs is required. Studies have proven that PSi has good biocompatibility, but the reports have been based on short‐term studies with small animals [54a,55] . Long‐term and detailed safety profiles are required to convince administrative agencies and pharmaceutical investors.…”

Section: Discussionmentioning

confidence: 99%

Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

et al. 2022

Self Cite

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The number of in vitro, ex vivo, and in vivo studies on porous silicon (PSi) nanoparticles for biomedical applications has increased extensively over the last decade. The focus of the reports has been on the carrier properties of PSi concerning the therapeutic aspect due to several beneficial nanovector characteristics including high payload capacity, biocompatibility, and versatile surface chemistry. Recently, increasing attention has been paid to the diagnostic aspects of PSi, which is typically attributed to the biotraceability of the nanovector. Also, PSi has been studied as a contrast agent. When both these aspects, therapy and diagnosis, are integrated into one nanovector, we can discuss a real nanotheranostics approach. Herein, we review the recent progress developing PSi for various imaging modalities, specifically focusing on optical imaging, magnetic resonance imaging, and nuclear medicine imaging. Furthermore, we summarized the knowledge gaps that must be covered before applying PSi in clinical imaging, highlighting future research trends.

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“…[258] On the other hand, polymer coating with PEG is commonly utilized for prolonged circulation and reduced clearance by immune system. [259] Targeting moieties such as peptides are used to enhance active tumor targeting. However, the surface functionalization of Au NS with PEG, peptide, and HA significantly decreased their PCE.…”

Section: Discussionmentioning

confidence: 99%

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

Wen

Tamarov

Happonen

et al. 2020

Advanced Therapeutics

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Inorganic photothermal agents (PTAs) have attracted considerable attention in cancer theranostics due to their unique features such as high photothermal conversion efficacy, excellent photothermal stability, and straightforward functionalization. The first part of this Review summarizes progress in methods for synthesizing PTAs, then considers in vitro photothermal evaluations, as well as in vivo photothermal-based applications that attempt to overcome different barriers in cancer theranostics. Next, a clinical trial with an inorganic PTA is described. The final part of the Review examines the challenges and possibilities for successful transfer of inorganic PTAs from the laboratory to the clinic.

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Approaches to improve the biocompatibility and systemic circulation of inorganic porous nanoparticles

Abstract: The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common.

Cited by 36 publications

References 120 publications

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

<p>Synthesis of Silver Nanoparticles Using a Novel Cyanobacteria <em>Desertifilum</em> sp. extract: Their Antibacterial and Cytotoxicity Effects</p>

Recent Developments in Porous Silicon Nanovectors with Various Imaging Modalities in the Framework of Theranostics

Inorganic Nanomaterials for Photothermal‐Based Cancer Theranostics

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