Approaches to Improve Therapeutic Efficacy of Biodegradable PLA/PLGA Microspheres: A Review

Bee, Soo‐Ling; Hamid, Zuratul Ain Abdul; Mariatti, M.; Yahaya, Badrul Hisham; Lim, Kok‐Geng; Bee, Soo‐Tueen; Sin, Lee Tin

doi:10.1080/15583724.2018.1437547

Cited by 75 publications

(67 citation statements)

References 170 publications

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“…However, a single antigen encapsulation strategy limits the antigen-loading efficiency and stability of PLGA nanoparticles. Many efforts have been made to increase the loading efficiency of nanoparticles, including altering particle size, shape, surface potential, and polymer types 34,35. Using these strategies, loading efficiency and stability of nanoparticles have been improved.…”

Section: Discussionmentioning

confidence: 99%

<p>Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses</p>

Wusiman¹,

Liu

et al. 2019

IJN

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Background: Poly (lactic-co-glycolic acid) (PLGA) nanoparticles and surface modified PLGA nanoparticles have been widely studied as antigens or drugs carriers due to their controlled release characteristics and biocompatibility. However, most PLGA nanoparticles have lower antigens loading efficiency and adjuvanticity. Purpose: The aim of this study was to improve the antigen loading efficiency and adjuvant activity of PLGA nanoparticles. Materials and methods: Surface cationic polymer modification can improve the antigens loading efficiency of PLGA nanoparticles by surface adsorption. Therefore, in this study, chitosan modified PLGA nanoparticles (CS-AHPP/OVA), polyethyleneimine modified PLGA nanoparticles (PEI-AHPP/OVA), and ε-Poly-L-lysine modified PLGA nanoparticles (εPL-AHPP/OVA) were prepared as antigen delivery carriers to investigate the characterization and stability of these nanoparticles. These nanoparticles were evaluated for their efficacies as adjuvants pre- and post-modification. Results: The AHP and OVA-loaded PLGA nanoparticles (AHPP/OVA) were positively charged after surface cationic polymers modification, and their structural integrity was maintained. Their antigen loading capacity and stability of nanoparticles were improved by the surface cationic polymers modification. Increased positive surface charge resulted in greater OVA adsorption capacity. Among AHPP/OVA and the three surface cationic polymers synthesized from modified PLGA nanoparticles, PEI-AHPP/OVA showed the highest antigen loading efficiency and good stability. AHPP/OVA, CS-AHPP/OVA PEI-AHPP/OVA, and εPL-AHPP/OVA formulations significantly enhanced lymphocyte proliferation and improved the ratio of CD4+/CD8+ T cells. In addition, AHPP/OVA, PEI-AHPP/OVA and εPL-AHPP/OVA formulations induced secretion of cytokines (TNF-α, IFN-γ, IL-4, and IL-6), antibodies (IgG) and antibody subtypes (IgG1 and IgG2a) in immunized mice. These results demonstrate that these formulations generated a strong Th1-biased immune response. Among them, PEI-AHPP/OVA induced the strongest Th1-biased immune response. Conclusion: In conclusion, PEI-AHPP/OVA nanoparticles may be a potential antigen delivery system for the induction of strong immune responses.

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Section: Discussionmentioning

confidence: 99%

<p>Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses</p>

Wusiman¹,

Liu

et al. 2019

IJN

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“…Continuous innovation in particulate formulations is under process to overcome disadvantages, including low drug loading capacity, low encapsulation efficiency, and terminal sterilization (Lee, Yun, & Park, 2016). Similarly, PLA-based microspheres are also under development for biomedical applications (Bee et al, 2018).…”

Section: Polylactic Acidmentioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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“…Complementarily, natural polysaccharides and proteins are well known to better promote animal cell adhesion through non-specific interactions (ionic force) or specific recognitions (adhesive peptide sequences specifically recognized by adhesion proteins expressed by animal cells) [14][15][16][17]. To enhance cell adhesion and growth onto polyester-based microspheres, surface post-modification is widely used [13,18]. This approach requires additional operational steps, such as preliminary surface activation/functionalization, bioactive component immobilization/deposition, washing out, etc., and the application of components, which could be potentially hazardous in terms of further application in biomedicine.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers

et al. 2020

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Self-stabilizing biodegradable microcarriers were produced via an oil/water solvent evaporation technique using amphiphilic chitosan-g-polyester copolymers as a core material in oil phase without the addition of any emulsifier in aqueous phase. The total yield of the copolymer-based microparticles reached up to 79 wt. %, which is comparable to a yield achievable using traditional emulsifiers. The kinetics of microparticle self-stabilization, monitored during their process, were correlated to the migration of hydrophilic copolymer’s moieties to the oil/water interface. With a favorable surface/volume ratio and the presence of bioadhesive natural fragments anchored to their surface, the performance of these novel microcarriers has been highlighted by evaluating cell morphology and proliferation within a week of cell cultivation in vitro.

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Approaches to Improve Therapeutic Efficacy of Biodegradable PLA/PLGA Microspheres: A Review

Cited by 75 publications

References 170 publications

<p>Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses</p>

<p>Cationic polymer modified PLGA nanoparticles encapsulating Alhagi honey polysaccharides as a vaccine delivery system for ovalbumin to improve immune responses</p>

Nanodiamond in composite: Biomedical application

Biodegradable Cell Microcarriers Based on Chitosan/Polyester Graft-Copolymers

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