Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) play a critical role in the osseointegration of bone and orthopedic implant. However, osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent defects. Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate. Here, we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys. We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration, and discuss recent advances in understanding their role in regenerative medicine. We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue

“…Ceramics with structural similarity to these minerals, such as hydroxyapatite (HA), calcium phosphate (CaP), tri-calcium phosphate (TCP) have been sourced for bone regeneration [ 66 ]. However, there are distinct differences in the osteogenic promoting properties of these materials in vivo between species, which often lead to encouraging pre-clinical studies but poor human clinical outcomes [ 67 , 68 ]. Other ceramics including coral, bioactive glass ceramics, silicon dioxide (SiO 2 ), zirconium oxide (ZrO 2 ), titanium dioxide (TiO 2 ) and metal alloys, such as titanium (Ti) and Mg have also been utilized in scaffold synthesis [ 63 , 64 , 65 , 69 ].…”

“…New tissue engineering approaches are being employed to generate composite hydrogels/scaffolds combining biopolymers, materials, small molecules or cells for enriched skeletal regeneration [ 55 , 65 , 67 ]. For example, Liu and colleagues have modified the chitosan (CS) hydrogels, incorporating catechol (CA), to improve the adhesive properties of the hydrogel, and zeolitic imidazolate framework-8 nanoparticle (ZIF-8 NP), where zinc displays antibacterial properties, and contributes to angiogenesis and osteogenesis [ 77 ].…”

Semaphorin3B Promotes Proliferation and Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells in a High-Glucose Microenvironment

“…Bone marrow mesenchymal stem cells (BMSCs) are characterized by differentiation into various types of cells, such as osteoblasts, chondrocytes, and other cell types [1][2][3]. BMSCs play a critical role in osteogenesis and bone metabolism [1][2][3][4][5][6].…”

“…Bone marrow mesenchymal stem cells (BMSCs) are characterized by differentiation into various types of cells, such as osteoblasts, chondrocytes, and other cell types [1][2][3]. BMSCs play a critical role in osteogenesis and bone metabolism [1][2][3][4][5][6]. Inhibition of the proliferation and osteogenic differentiation of BMSCs induces dysfunction of bone metabolism and gives rise to multiple bone loss diseases, including osteoporosis, periodontitis, and dental implantation failure [2,7,8].…”

The Body’s Cellular and Molecular Response to Protein-Coated Medical Device Implants: A Review Focused on Fibronectin and BMP Proteins

“…The body’s response to a titanium implant is complex. Huo and Yue [ 119 ] reviewed many of the studies describing various coatings and surface treatments of titanium and its alloys, with a main focus on physical and chemical treatments. In many respects, the response resembles wound healing, because placement of the implant involves producing a wound.…”