The cultivation of higher plants occupies an essential role within bio-regenerative life support systems. It contributes to all major functional aspects by closing the different loops in a habitat like food production, CO 2 reduction, O 2 production, waste recycling and water management. Fresh crops are also expected to have a positive impact towards the crew's psychological health. Nevertheless, plant cultivation in closed environments is challenging and further research on system, subsystem and crop level is required. The controlling and maintaining of closed environment agriculture systems such as space greenhouse modules is difficult due to lack of buffer capacity, low flexibility concerning varying crew size and eclipse periods, and the absence of backup systems in case of plant and system failures. The addition of physico-chemical (P/C) life support systems (LSS) as an intermediate system between the greenhouse module and the habitat/spacecraft has the potential to reduce or even eliminate the mentioned difficulties of greenhouse modules. This paper will investigate the potential of combining components of physico-chemical systems with greenhouse modules to increase the readiness of the latter. This would allow the creation of a more efficient life support systems by taking advantage of the experience gained in physico-chemical technologies and the related reliability and heritage of these technologies.