Approaches to the management of pediatric ovarian masses in the 21st century: Systematic review and meta-analysis

Qazi, Saqib Hamid; Jeelani, Sarah Masroor; Dogar, Sohail Asghar; Das, Jai K; Saxena, Amulya K.

doi:10.1016/j.jpedsurg.2019.09.003

Cited by 16 publications

(13 citation statements)

References 47 publications

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“…Most ovarian masses in pediatric and adolescent patients are physiologic or benign. Of ovarian lesions managed operatively, the reported rate of malignancy is 10%–20%, which comprises approximately 1%–2% of all childhood malignancies 14 . A Decision Tree System has been proposed to aid determination of which masses are malignant before surgery, using a morphology index and ovarian crescent sign, whereas other studies have shown that using a measurement of 8 cm or greater with a complex/solid appearance of the mass predicts a higher risk of malignancy 15,16 .…”

Section: Adnexal Massesmentioning

confidence: 99%

Pediatric and adolescent gynecology through a global lens

Roos

Simms‐Cendan

Cheung

et al. 2021

Intl J Gynecology & Obste

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Girls and adolescents, aged 0–19 years make up almost 30% of the world’s female population yet their specific healthcare needs often slip between the gaps of pediatrics and adult women’s health. Pediatric and adolescent gynecology is the clinical field that endeavors to address the reproductive health needs of this age group. The environment and psychosocial well‐being, social determinants of health, have direct bearing on reproductive health, affecting menstrual cycles, menstrual hygiene, and risks for unintended pregnancy and sexually transmitted infections. This narrative review will highlight common gynecologic conditions of adolescents, especially where diagnosis and management are distinct from adult women. It will also present preventive health strategies to improve reproductive health through vaccination, improved access to hygiene supplies and contraception.

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Section: Adnexal Massesmentioning

confidence: 99%

Pediatric and adolescent gynecology through a global lens

Roos

Simms‐Cendan

Cheung

et al. 2021

Intl J Gynecology & Obste

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show abstract

“…Ultrasonography is the most important and non-invasive diagnostic tool for cyst evaluation. A number of criteria with particular reference to the size of the cyst or tumour, echogenicity, and the presence of solid components of the cyst may facilitate pre-operative diagnosis [ 8 , 9 ]. Cysts containing a solid component with concomitant elevated levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (β-hCG), foetal-cancer antigen (CEA), alkaline phosphatase, or cancer antigen 125 (CA-125) and no regression in the size range of the cyst during a 3-month ultrasonographic observation arouse suspicion of malignant changes and require surgery [ 7 , 9 ].…”

Section: Ovarian Cyst Surgerymentioning

confidence: 99%

“…A number of criteria with particular reference to the size of the cyst or tumour, echogenicity, and the presence of solid components of the cyst may facilitate pre-operative diagnosis [ 8 , 9 ]. Cysts containing a solid component with concomitant elevated levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (β-hCG), foetal-cancer antigen (CEA), alkaline phosphatase, or cancer antigen 125 (CA-125) and no regression in the size range of the cyst during a 3-month ultrasonographic observation arouse suspicion of malignant changes and require surgery [ 7 , 9 ]. In addition to the oncological indications, patients whose cyst diameter has not decreased in ultrasound over a period of 3 months, patients with recurrent pain, signs of intra-abdominal compression, and intestinal passage disorders, or patients with ‘acute abdominal’ symptoms are eligible for ovarian cyst surgery [ 7 ].…”

Section: Ovarian Cyst Surgerymentioning

confidence: 99%

“…The most popular method of cyst content aspiration described in the literature is peritoneal aspiration of an ovarian cyst under direct control of laparoscopy with cyst wall resection and getting it out with an endo-catch. However, this is not a method that guarantees that the contents of the cyst will not leak into the abdominal cavity [ 9 ]. According to the published literature the rates of intraoperative leakage of ovarian cyst contents during laparoscopic procedures range from 0% to 100% [ 9 ].…”

Section: Ovarian Cyst Surgerymentioning

confidence: 99%

“…However, this is not a method that guarantees that the contents of the cyst will not leak into the abdominal cavity [ 9 ]. According to the published literature the rates of intraoperative leakage of ovarian cyst contents during laparoscopic procedures range from 0% to 100% [ 9 ]. However, complications such as peritonitis or adhesions leading to loss of fertility in the paediatric population are minimal [ 11 ].…”

Section: Ovarian Cyst Surgerymentioning

confidence: 99%

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The role of laparoscopy in paediatric and adolescent gynaecology.

Raźnikiewicz

Korlacki

Grabowski

2020

Videosurgery and Other Miniinvasive Techniques

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Paediatric and adolescent gynaecology is a narrow field of medicine dealing with the diagnosis of and treatment of gynaecological diseases from the neonatal period to sexual maturity. The current trend in surgical gynaecology in the paediatric population is to minimise the degree of invasiveness of diagnostic and therapeutic procedures. This contributes to reducing the number of complications and the risk of infertility. Laparoscopic procedures are a challenge for paediatric surgeons and gynaecologists, not only because of the age of treated patients, and anatomical and physiological differences between different age groups but also because of the complexity of the pathology, the differentiation of cancer tumours, and the presence of congenital developmental defects.

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Pediatric Ovarian Yolk Sac Tumor Mimicking Appendicitis: A Case Report From a Low‐Resource Setting

Nkenguye,

Mremi,

Minja

et al. 2024

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Ovarian yolk sac tumors (OYSTs), also known as endodermal sinus tumors, are rare and highly malignant germ cell tumors, accounting for approximately 1% of all ovarian cancers. They predominantly affect children and young adults, with a rapid growth rate and early metastasis, making early diagnosis and treatment crucial. This report presents the case of a 6‐year‐old female from a low‐resource setting who initially presented with symptoms suggestive of acute appendicitis, including abdominal pain, fever, and vomiting. This was supported by a CT scan; however, intraoperative findings revealed a large right ovarian mass, which was surgically excised via cystectomy and histologically confirmed as an OYST. The patient recovered well postoperatively and was referred for oncological management. This case underscores the importance of considering OYSTs in the differential diagnosis of pediatric abdominal masses and highlights the necessity of a multidisciplinary approach for optimal patient outcomes. Enhanced awareness and improved diagnostic strategies are essential for better management of this rare tumor, particularly in resource‐limited settings.

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Approaches to the management of pediatric ovarian masses in the 21st century: Systematic review and meta-analysis

Cited by 16 publications

References 47 publications

Pediatric and adolescent gynecology through a global lens

Pediatric and adolescent gynecology through a global lens

The role of laparoscopy in paediatric and adolescent gynaecology.

Pediatric Ovarian Yolk Sac Tumor Mimicking Appendicitis: A Case Report From a Low‐Resource Setting

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