Approaches to the Selection of Excipients for Dental Gel With Cetylpyridinium Chloride

Загорулько, Е. Ю.; Караваева, A. С.

doi:10.19163/2307-9266-2021-9-1-54-63

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…As a strongly polar substance, NaF likely exhibited good competitive hydration that extensively influenced the hydration and/or aggregation behavior of the macromolecules, leading to the impaired gel forming ability of HPMC (Hao et al, 2018). In addition, the cellulose gels were reported to lose their homogenous structure, and eventually precipitated out upon incorporation of the flower extract (Aslani et al, 2016) and cetylpyridinium chloride (Zagorulko, & Karavaeva, 2021).…”

Section: Discussionmentioning

confidence: 99%

Development of 2% w/w sodium fluoride oral gels for prevention of dental caries in patients with xerostomia

Chidchonnee Kosolpatanadurong,

Chirasak Kusonwiriyawong

2023

JCST

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For prevention of dental caries in xerostomic patients, 2% w/w sodium fluoride oral gel is frequently prescribed; however, the product has not been officially approved for clinical use in Thailand. Therefore, this study aimed to develop 2% w/w sodium fluoride oral gels dispensed specifically to patients in Rajavithi Hospital. Both single and combined gel bases were prepared from different gelling agents, including gelatin, xanthan gum, hydroxypropyl methylcellulose, sodium carboxymethylcellulose, and Carbopol 940P. They were subsequently characterized according to their physicochemical properties, i.e., clarity, spreadability, pH values, and apparent viscosity. All the gel bases were clear viscous liquids of good spreadability, except the xanthan gum gel bases, which were slightly cloudy. The pH values indicate that the gelatin, xanthan gum, and Carbopol 940P gel bases were acidic, while the cellulose gel bases were neutral. The apparent viscosity ranged from 3 to 11.5 x 105 cPs, depending mainly on type and concentration of the gelling agents. After preparation, the gel bases were then incorporated with 1 M pH 7.4 phosphate buffer solution to the final concentration of 5% w/w. Macroscopic characteristics of the buffered gel bases were generally unchanged, except for the apparent viscosity, which decreased slightly. Sodium fluoride was subsequently added to the selected buffered gel bases. The resulting sodium fluoride gels were neutral and transparent viscous liquids of good spreadability and exhibited good stability against the heating-cooling cycle and accelerated testing. Thus, it is conceivable that 2% w/w sodium fluoride oral gels with acceptable physicochemical characteristics and excellent stability were successfully developed.

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Section: Discussionmentioning

confidence: 99%

Development of 2% w/w sodium fluoride oral gels for prevention of dental caries in patients with xerostomia

Chidchonnee Kosolpatanadurong,

Chirasak Kusonwiriyawong

2023

JCST

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“…Характерные свойства гелей -одновременно твердого тела и жидкости -делают их одними из самых современных средств в практической медицине. Гели имеют простую технологию и комфортны в применении [1][2][3][4][5][6][7][8][9][10][11]. Стоматологические гели как твердое тело обладают способностью задерживаться на зубах, и как жидкость гели эффективны при аппликационном воздействии.…”

Section: Introductionunclassified

Validation of Analytical Methods for Quality Control of Gel for Dentin Remineralization

Golovanenko,

Berezina,

Alekseeva

et al. 2023

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. As a result of a complex of scientific and experimental studies carried out at the Department of Pharmaceutical Technology of the State Pharmacy of Pharmaceuticals, a gel was developed for remineralization of dentin in order to carry out drug treatment of medium and deep caries. In the developed gel, along with the remineralizing effect, an antibacterial effect was achieved, which is necessary in the treatment of dentin caries due to the introduction of chlorhexidine bigluconate (CHB). The proposed composition simultaneously contains the main remineralizing ions – calcium, phosphate and fluoride in a free active state. Due to this, a significant increase in their penetration into the dentin is ensured. During the preparation of regulatory documentation for the gel for the treatment of dentine caries, validation of methods designed to control the quality of active substances was carried out.Aim. Validation of methods for testing the authenticity and quantification of active substances in the gel for dentine remineralization.Materials and methods. To achieve this goal, active pharmaceutical substances of pharmacopoeial quality are used. When developing test methods, pharmacopoeial and non-pharmacopoeial reactions to reacting cations and anions were used. For the quantitative determination of the chloride compound, the complexometric method, the back titration method is used, for potassium phosphate, the disubstituted acidimetric method, for sodium fluoride, the photoelectrocolorimetric method, for chlorhexidine bigluconate, the lauryl sulfate method. The objects of study were five serial samples of gels.Results and discussion. As a result of the studies, methods of testing for authenticity were developed, it was found that the proposed methods are characterized by a negative analytical signal on model mixtures free of the analyte and placebo, and a positive analytical signal on model mixtures of various compositions containing the analyte. The validation characteristics of methods for the quantitative determination of active substances in the gel were studied, positive results were obtained, the proposed methods can be used for inclusion in the regulatory documentation for the developed gel.Conclusion. When evaluating the validation characteristics of the proposed methods, it was found that the methods of testing for authenticity and quantitative determination of active substances in the gel are specific, the methods of quantitative determination are characterized by accuracy and repeatability, a linear dependence in the analytical region of ±20 % of the declared amount of active substances, which allows them to be used for reliable assessment of the quality of the developed gel.

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Relevance of the Development of Dental <i>In situ</i> Implant for Post-resection Therapy (Review)

Pomytkina,

Bakhrushina,

Sakharova

et al. 2024

Razrabotka i registraciâ lekarstvennyh sredstv

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Introduction. The problem of pain relief after surgery is relevant in modern dentistry, as pain control is an important part of treatment. In addition to anesthesia, there are other problems of post-resection therapy such as bleeding from the wound and inflammation. Modern dental practice does not have a targeted delivery system or a medical product with analgesic, anti-inflammatory, anesthetic or hemostatic action, which ensures high adherence of patients to the ongoing post-resection therapy.Text. To solve this problem, it can be proposed to develop an in situ implant – a dosage form that is formed directly at the injection site, in the alveolar socket. Targeted delivery system has advantages: no need to use a medical dressing material; no risk of secondary contamination; dosing accuracy and target delivery to the lesion locus; high mucoadhesion to the site of application; the duration of the active ingredient release and others. The purpose of the review is to substantiate the possibility and relevance of developing a new in situ implant system for use in dental post-resection practice. The study was conducted on the main databases of publications (Scopus, Web of Science, PubMed and others), and patent search database on materials published from 2000 to the present. The study describes the currently existing in situ systems for dental problems, which could be a prototype of systems for delivering an anesthetic directly to the tooth socket, the polymers used to create them and the possibility of releasing drugs, and also characterizes existing drugs for the pain relief (applied both locally and for systemic action), in comparison with in situ systems, which have certain advantages and great potential for development.Conclusion. Based on the results of the work, a conclusion about the possibility of pharmaceutical development of dental in situ implants was made, and the most promising polymers for phase transition in the alveolar socket were identified.

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Approaches to the Selection of Excipients for Dental Gel With Cetylpyridinium Chloride

Cited by 3 publications

References 24 publications

Development of 2% w/w sodium fluoride oral gels for prevention of dental caries in patients with xerostomia

Development of 2% w/w sodium fluoride oral gels for prevention of dental caries in patients with xerostomia

Validation of Analytical Methods for Quality Control of Gel for Dentin Remineralization

Relevance of the Development of Dental <i>In situ</i> Implant for Post-resection Therapy (Review)

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