This manuscript presents a study on the spatial relationships between bike accidents, the built environment, land use, and transportation network characteristics in Budapest, Hungary using geographic weighted regression (GWR). The sample period includes bike crash data between 2017 and 2022. The findings provide insights into the spatial distribution of bike crashes and their severity, which can be useful for designing targeted interventions to improve bike safety in Budapest and be useful for policymakers and city planners in developing effective strategies to reduce the severity of bike crashes in urban areas. The study reveals that built environment features, such as traffic signals, road crossings, and bus stops, are positively correlated with the bike crash index, particularly in the inner areas of the city. However, traffic signals have a negative correlation with the bike crash index in the suburbs, where they may contribute to making roads safer for cyclists. The study also shows that commercial activity and PT stops have a higher impact on bike crashes in the northern and western districts. GWR analysis further suggests that one-way roads and higher speed limits are associated with more severe bike crashes, while green and recreational areas are generally safer for cyclists. Future research should be focused on the traffic volume and bike trips’ effects on the severity index.