Approaching the mechanistic insights towards the genesis of intracellular calcium transient alternans - a simulation study

Abstract

Mechanical contraction alternans of the heart is associated with fatal cardiac death. It is manifested by Twave alternans in the ECG, and is thought to be possibly related to intracellular Ca 2+ transient alternans released from the sarcoplasmic reticulum (SR). However, it is unclear yet how beat-to-beat alternans of intracellular Ca 2+ transient is produced. In this study investigated the mechanism(s) underlying the genesis of intracellular Ca 2+ alternans produced at slow pacing rates by using a mathematical model of a spatially extended cardiac cell with a cluster of coupled ryanodine receptor (RyR) elements. It was shown that the intracellular Ca 2+ alternans was generated by propagating waves of Ca 2+ release and sustained through alternation of SR Ca 2+ content that has a stiff relationship with the Ca 2+ transient. This study provides novel and fundamental insights to understand mechanisms that may underlie intracellular Ca 2+ alternans without the need for refractoriness of L-type Ca or RyR channels under rapid pacing.

Patterns of Calcium Signaling based on HH Model

“…According to the Brownian dynamics model shows the curve against time, displacement and average velocity of calcium ions which showing the ELF magnetic field. [4,5]. The capacity of calcium channels also based on the inter celluler based wave model which is basically called calcium signaling which is used by the widespread range of the different organism with different types of cells.…”